Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme

Tao Wang, Xiangbin Zhang, Poonam Bheda, Javier R. Revollo, Shin Ichiro Imai, Cynthia Wolberger

Research output: Contribution to journalArticle

Abstract

Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.

Original languageEnglish (US)
Pages (from-to)661-662
Number of pages2
JournalNature Structural and Molecular Biology
Volume13
Issue number7
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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