TY - JOUR
T1 - Structure of a murine leukemia virus receptor-binding glycoprotein 2.0 angstrom resolution
AU - Fass, Deborah
AU - Davey, Robert A.
AU - Hamson, Christian A.
AU - Kim, Peter S.
AU - Cunningham, James M.
AU - Berger, James M.
PY - 1997/9/12
Y1 - 1997/9/12
N2 - An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel β sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the B sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.
AB - An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel β sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the B sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.
UR - http://www.scopus.com/inward/record.url?scp=0030820095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030820095&partnerID=8YFLogxK
U2 - 10.1126/science.277.5332.1662
DO - 10.1126/science.277.5332.1662
M3 - Article
C2 - 9287219
AN - SCOPUS:0030820095
SN - 0036-8075
VL - 277
SP - 1662
EP - 1666
JO - Science
JF - Science
IS - 5332
ER -