Structure of a murine leukemia virus receptor-binding glycoprotein 2.0 angstrom resolution

Deborah Fass, Robert A. Davey, Christian A. Hamson, Peter S. Kim, James M. Cunningham, James M. Berger

Research output: Contribution to journalArticlepeer-review

Abstract

An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel β sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the B sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.

Original languageEnglish (US)
Pages (from-to)1662-1666
Number of pages5
JournalScience
Volume277
Issue number5332
DOIs
StatePublished - Sep 12 1997
Externally publishedYes

ASJC Scopus subject areas

  • General

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