Structure-function correlation of the human central retina

Peter Charbel Issa, Eric Troeger, Robert Finger, Frank G. Holz, Robert Wilke, Hendrik P N Scholl

Research output: Contribution to journalArticle

Abstract

Background: The impact of retinal pathology detected by high-resolution imaging on vision remains largely unexplored. Therefore, the aim of the study was to achieve high-resolution structure-function correlation of the human macula in vivo. Methodology/Principal Findings: To obtain high-resolution tomographic and topographic images of the macula spectraldomain optical coherence tomography (SD-OCT) and confocal scanning laser ophthalmoscopy (cSLO), respectively, were used. Functional mapping of the macula was obtained by using fundus-controlled microperimetry. Custom software allowed for co-registration of the fundus mapped microperimetry coordinates with both SD-OCT and cSLO datasets. The method was applied in a cross-sectional observational study of retinal diseases and in a clinical trial investigating the effectiveness of intravitreal ranibizumab in macular telangietasia type 2. There was a significant relationship between outer retinal thickness and retinal sensitivity (p

Original languageEnglish (US)
Article numbere12864
Pages (from-to)1-9
Number of pages9
JournalPLoS One
Volume5
Issue number9
DOIs
StatePublished - 2010

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Ophthalmoscopy
Optical tomography
tomography
Optical Coherence Tomography
retina
lasers
Retina
Lasers
Scanning
retinal diseases
Retinal Diseases
Pathology
observational studies
Observational Studies
clinical trials
Software
Cross-Sectional Studies
Clinical Trials
image analysis
Imaging techniques

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Issa, P. C., Troeger, E., Finger, R., Holz, F. G., Wilke, R., & Scholl, H. P. N. (2010). Structure-function correlation of the human central retina. PLoS One, 5(9), 1-9. [e12864]. https://doi.org/10.1371/journal.pone.0012864

Structure-function correlation of the human central retina. / Issa, Peter Charbel; Troeger, Eric; Finger, Robert; Holz, Frank G.; Wilke, Robert; Scholl, Hendrik P N.

In: PLoS One, Vol. 5, No. 9, e12864, 2010, p. 1-9.

Research output: Contribution to journalArticle

Issa, PC, Troeger, E, Finger, R, Holz, FG, Wilke, R & Scholl, HPN 2010, 'Structure-function correlation of the human central retina', PLoS One, vol. 5, no. 9, e12864, pp. 1-9. https://doi.org/10.1371/journal.pone.0012864
Issa PC, Troeger E, Finger R, Holz FG, Wilke R, Scholl HPN. Structure-function correlation of the human central retina. PLoS One. 2010;5(9):1-9. e12864. https://doi.org/10.1371/journal.pone.0012864
Issa, Peter Charbel ; Troeger, Eric ; Finger, Robert ; Holz, Frank G. ; Wilke, Robert ; Scholl, Hendrik P N. / Structure-function correlation of the human central retina. In: PLoS One. 2010 ; Vol. 5, No. 9. pp. 1-9.
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