Structure-based thermodynamic analysis of HIV-1 protease inhibitors

Medicine & Life Sciences

• Abbott 77003 100%
• Human immunodeficiency virus 1 p16 protease 69%
• HIV Protease Inhibitors 67%
• 2-phenylmethyl-4-hydroxy-5-(tert-butoxycarbonyl)amino-6-phenylhexanoyl-N-(1'-imidazol-2-yl)-2-'-methylpropanamide 59%
• Thermodynamics 56%
• Peptide Hydrolases 38%
• Binding Sites 35%
• Mutation 25%
• Protease Inhibitors 23%
• Proteins 8%
• SB 206343 3%
• SB 203238 3%
• A 74704 3%

Chemical Compounds

• U100313 55%
• Protease Inhibitor 54%
• Mutation 39%
• Binding Site 32%
• Inhibition Constant 28%
• Kd 17%
• Gibbs Free Energy 17%
• Protein 9%
• Molecule 8%