Structure and molecular regulation of bone matrix proteins

Pamela Gehron Robey, Neal S Fedarko, Theresa E. Hefferan, Paolo Bianco, Ulrich K. Vetter, Wojciech Grzesik, Alexander Friedenstein, Gabri Van Der Pluijm, Keith P. Mintz, Marian F. Young, Janet M. Kerr, Kyomi Ibaraki, Anne Marie Heegaard

Research output: Contribution to journalArticle

Abstract

The organic matrix of bone contains several protein families, including collagens, proteoglycans, and glycoproteins, all of which may be extensively modified by posttranslational events, such as phosphorylation and sulfation. Many of the glycoproteins contain Arg-Gly-Asp (RGD), the integrin-binding sequence, within their structure, whereas other constituent proteins contain gamma-carboxyglutamic acid. The deposition of bone matrix by cells in the osteoblastic lineage is regulated by extrinsic factors, such as systemic and local growth factors and physical forces, and factors that are intrinsic to the cell, such as position in the cell cycle, maturational stage, and developmental age of the donor. Recent studies of several bone matrix gene promoters have identified cis- and trans-acting elements that are responsible for gene activity, although the precise sequence of regulatory events is not known. Development of in vitro assays, coupled with studies of the appearance of these proteins during development in vivo, provides insight into the functions of these proteins during the various stages of bone metabolism. Potential roles for these proteins include proliferation and maturation of stem cells, formation of matrix scaffolding elaborated by bone-forming cells, modeling, and remodeling. Changes in the functional properties of the extracellular matrix may be involved in a variety of disease processes, including osteoporosis and oral bone loss.

Original languageEnglish (US)
JournalJournal of Bone and Mineral Research
Volume8
Issue numberSUPPL. 2
StatePublished - Dec 1993
Externally publishedYes

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Bone Matrix
Molecular Structure
Proteins
Bone and Bones
Glycoproteins
1-Carboxyglutamic Acid
Intrinsic Factor
Proteoglycans
Integrins
Genes
Osteoporosis
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Cell Cycle
Collagen
Stem Cells
Phosphorylation

ASJC Scopus subject areas

  • Surgery

Cite this

Robey, P. G., Fedarko, N. S., Hefferan, T. E., Bianco, P., Vetter, U. K., Grzesik, W., ... Heegaard, A. M. (1993). Structure and molecular regulation of bone matrix proteins. Journal of Bone and Mineral Research, 8(SUPPL. 2).

Structure and molecular regulation of bone matrix proteins. / Robey, Pamela Gehron; Fedarko, Neal S; Hefferan, Theresa E.; Bianco, Paolo; Vetter, Ulrich K.; Grzesik, Wojciech; Friedenstein, Alexander; Van Der Pluijm, Gabri; Mintz, Keith P.; Young, Marian F.; Kerr, Janet M.; Ibaraki, Kyomi; Heegaard, Anne Marie.

In: Journal of Bone and Mineral Research, Vol. 8, No. SUPPL. 2, 12.1993.

Research output: Contribution to journalArticle

Robey, PG, Fedarko, NS, Hefferan, TE, Bianco, P, Vetter, UK, Grzesik, W, Friedenstein, A, Van Der Pluijm, G, Mintz, KP, Young, MF, Kerr, JM, Ibaraki, K & Heegaard, AM 1993, 'Structure and molecular regulation of bone matrix proteins', Journal of Bone and Mineral Research, vol. 8, no. SUPPL. 2.
Robey PG, Fedarko NS, Hefferan TE, Bianco P, Vetter UK, Grzesik W et al. Structure and molecular regulation of bone matrix proteins. Journal of Bone and Mineral Research. 1993 Dec;8(SUPPL. 2).
Robey, Pamela Gehron ; Fedarko, Neal S ; Hefferan, Theresa E. ; Bianco, Paolo ; Vetter, Ulrich K. ; Grzesik, Wojciech ; Friedenstein, Alexander ; Van Der Pluijm, Gabri ; Mintz, Keith P. ; Young, Marian F. ; Kerr, Janet M. ; Ibaraki, Kyomi ; Heegaard, Anne Marie. / Structure and molecular regulation of bone matrix proteins. In: Journal of Bone and Mineral Research. 1993 ; Vol. 8, No. SUPPL. 2.
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