Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

Barry D. Nelkin; Kenneth I. Rosenfeld; Andrée de Bustros; Susan S. Leong; Bernard A. Roos; Stephen B. Baylin

doi:10.1016/0006-291X(84)90278-X

Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

Barry D. Nelkin, Kenneth I. Rosenfeld, Andrée de Bustros, Susan S. Leong, Bernard A. Roos, Stephen B. Baylin

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.

Original language	English (US)
Pages (from-to)	648-655
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	123
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(84)90278-X
State	Published - Sep 17 1984

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(84)90278-X

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title = "Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide",

abstract = "Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.",

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AU - Nelkin, Barry D.

AU - Rosenfeld, Kenneth I.

AU - de Bustros, Andrée

AU - Leong, Susan S.

AU - Roos, Bernard A.

AU - Baylin, Stephen B.

PY - 1984/9/17

Y1 - 1984/9/17

N2 - Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.

AB - Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.

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Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

Abstract

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