Abstract
The recent structure and associated biochemical studies of the metazoan-specific p300/CBP and fungal-specific Rtt109 histone acetyltransferases (HATs) have provided new insights into the ancestral relationship between HATs and their functions. These studies point to a common HAT ancester that has evolved around a common structural framework to form HATs with divergent catalytic and substrate-binding properties. These studies also point to the importance of regulatory loops within HATs and autoacetylation in HAT function. Implications for future studies are discussed.
Original language | English (US) |
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Pages (from-to) | 741-747 |
Number of pages | 7 |
Journal | Current Opinion in Structural Biology |
Volume | 18 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2008 |
Externally published | Yes |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology