Structure and alternative splicing of the gene encoding α(1I), a human brain T calcium channel α1 subunit

Scott Mittman, Jing Guo, Mark C. Emerick, William S. Agnew

Research output: Contribution to journalArticle

Abstract

The structure of CACNA1I, the gene encoding α(1I), a human brain T Ca2+ channel α1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 36 exons spanning at least 115 168 basepairs of chromosome 22q12.3- 13.2. The predicted protein has 2016 amino acids and 28 potential phosphorylation sites. Alternative splicing of the gene occurs at two sites: cassette exon 9 and an alternative acceptor in exon 33. Molecular diversity generated by alternative splicing and post-translational modification of this and other members of the T α1 subunit gene family may account for the observed heterogeneity of T currents in central neurons.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalNeuroscience Letters
Volume269
Issue number3
DOIs
StatePublished - Jul 16 1999

Keywords

  • Alternative splicing
  • CACNA1I
  • T-type calcium channel

ASJC Scopus subject areas

  • Neuroscience(all)

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