Structure and alternative splicing of the gene encoding α(1G), a human brain T calcium channel α1 subunit

Scott Mittman, Jing Guo, William S. Agnew

Research output: Contribution to journalArticle

Abstract

The structure of CACNA1G, the gene encoding α(1G), a human brain T Ca2+ channel α1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 38 exons, two of them newly-identified, spanning at least 66 490 basepairs of chromosome 17q22. Alternative splicing of the RNA occurs at six sites: cassette exons 14, 26, 34 and 35, an internal donor in exon 25 and protein-coding intron 38B. Additionally, the RNA can be polyadenylated at either of two sites. Alternative splicing of CACNA1G RNA may lead to expression of as many as 24 distinct protein products, ranging from 2171 to 2377 amino-acids residues. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalNeuroscience Letters
Volume274
Issue number3
DOIs
StatePublished - Oct 29 1999

Keywords

  • Alternative splicing
  • CACNA1G
  • T-type calcium channel

ASJC Scopus subject areas

  • Neuroscience(all)

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