Abstract
The structure of CACNA1I, the gene encoding α(1I), a human brain T Ca2+ channel α1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 36 exons spanning at least 115 168 basepairs of chromosome 22q12.3- 13.2. The predicted protein has 2016 amino acids and 28 potential phosphorylation sites. Alternative splicing of the gene occurs at two sites: cassette exon 9 and an alternative acceptor in exon 33. Molecular diversity generated by alternative splicing and post-translational modification of this and other members of the T α1 subunit gene family may account for the observed heterogeneity of T currents in central neurons.
Original language | English (US) |
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Pages (from-to) | 121-124 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 269 |
Issue number | 3 |
DOIs | |
State | Published - Jul 16 1999 |
Keywords
- Alternative splicing
- CACNA1I
- T-type calcium channel
ASJC Scopus subject areas
- General Neuroscience