Structural theory of the swelling pressure of corneal stroma in saline

R. W. Hart, R. A. Farrell

Research output: Contribution to journalArticle

Abstract

The swelling pressure of the corneal stroma is discussed in terms of a stromal model of collagen fibrils interconnected via protein-mucopolysaccharide molecular complexes. The analysis leads to an expression for the swelling pressure in terms of molecular parameters of the complexes regarded as polymeric chains. Assigning reasonable values to these parameters we find that the model is consistent with the swelling pressure experiments. These parameters indicate the electrostatic (Donnan) pressure component accounts for most of the swelling pressure at normal thickness in 0.174 M NaCl, while the pressure components deriving from a free energy of mixing account for most of the swelling pressure at normal thickness in 1.74 M NaCl.

Original languageEnglish (US)
Pages (from-to)165-186
Number of pages22
JournalThe Bulletin of Mathematical Biophysics
Volume33
Issue number2
DOIs
StatePublished - Jun 1971

Fingerprint

Corneal Stroma
Swelling
swelling
Pressure
Collagen
collagen
glycosaminoglycans
Glycosaminoglycans
Static Electricity
Electrostatics
Free energy
Free Energy
Proteins
Protein
protein
energy
Model

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)
  • Mathematics(all)
  • Immunology
  • Environmental Science(all)
  • Computational Theory and Mathematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine(all)

Cite this

Structural theory of the swelling pressure of corneal stroma in saline. / Hart, R. W.; Farrell, R. A.

In: The Bulletin of Mathematical Biophysics, Vol. 33, No. 2, 06.1971, p. 165-186.

Research output: Contribution to journalArticle

Hart, R. W. ; Farrell, R. A. / Structural theory of the swelling pressure of corneal stroma in saline. In: The Bulletin of Mathematical Biophysics. 1971 ; Vol. 33, No. 2. pp. 165-186.
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