Structural remodeling of cocaine: Design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors

Alan P. Kozikowski; Lianyun Zhao; Ao Zhang; Cheng Z. Wang; Judith Flippen-Anderson; Kenneth M. Johnson

doi:10.1002/cmdc.200500016

Structural remodeling of cocaine: Design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors

Alan P. Kozikowski, Lianyun Zhao, Ao Zhang, Cheng Z. Wang, Judith Flippen-Anderson, Kenneth M. Johnson

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.

Original language	English (US)
Pages (from-to)	58-65
Number of pages	8
Journal	ChemMedChem
Volume	1
Issue number	1
DOIs	https://doi.org/10.1002/cmdc.200500016
State	Published - Jan 2006
Externally published	Yes

Keywords

Cocaine
Cyclopropane
Monoamine inhibitors
Neurochemistry
Neurotransmitters

ASJC Scopus subject areas

Drug Discovery
General Pharmacology, Toxicology and Pharmaceutics
Molecular Medicine
Biochemistry
Pharmacology
Organic Chemistry

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10.1002/cmdc.200500016

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keywords = "Cocaine, Cyclopropane, Monoamine inhibitors, Neurochemistry, Neurotransmitters",

author = "Kozikowski, {Alan P.} and Lianyun Zhao and Ao Zhang and Wang, {Cheng Z.} and Judith Flippen-Anderson and Johnson, {Kenneth M.}",

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AU - Zhao, Lianyun

AU - Zhang, Ao

AU - Wang, Cheng Z.

AU - Flippen-Anderson, Judith

AU - Johnson, Kenneth M.

PY - 2006/1

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AB - Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.

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KW - Monoamine inhibitors

KW - Neurochemistry

KW - Neurotransmitters

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Structural remodeling of cocaine: Design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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