Structural proteins of ribonucleic acid tumor viruses. Purification of envelope, core, and internal components

M. Strand, J. T. August

Research output: Contribution to journalArticle

Abstract

Murine type C virus structural proteins, the envelope glycopeptides, 30,000 dalton major core protein, and 15,000 dalton internal protein have each been purified to near homogeneity and in high yield from the same batch of virus by use of phosphocellulose column chromatography and gel filtration procedures. Evidence that these proteins are specified by the viral genome was obtained by competition radioimmunoassay analysis, comparing these polypeptides from Rauscher virus cultivated in a variety of mammalian cell lines; all of the reactive antigenic determinants of these proteins appeared to be virus specific.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalJournal of Biological Chemistry
Volume251
Issue number2
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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