Structural modeling of dynamic changes in memory and brain structure using longitudinal data from the normative aging study

John J. McArdle, Fumiaki Hamgami, Kenneth Jones, Ferenc Jolesz, Ron Kikinis, Avron Spiro, Marilyn S. Albert

Research output: Contribution to journalArticle


This is an application of new longitudinal structural equation modeling techniques to time-dependent associations of memory and brain structure measurements. There were 225 participants aged 30-80 years at baseline who were measured again after a 7-year interval on both the lateral ventricular size and Wechsler memory score. Multiple regression analyses show nonlinear associations with age but no relationships among longitudinal changes. Mixed-effects latent growth curve analyses and analyses based on latent difference scores indicate that longitudinal changes in both variables are reasonably well described by an exponential or dual change model. Bivariate dynamic structural equation modeling analyses indicate age-lagged changes operate in a coupled-over-time fashion, with the brain measure (lateral ventricular size) as a leading indicator in time of memory (Wechsler memory score) declines.

Original languageEnglish (US)
Pages (from-to)P294-P304
JournalJournals of Gerontology - Series B Psychological Sciences and Social Sciences
Issue number6
StatePublished - Nov 2004
Externally publishedYes


ASJC Scopus subject areas

  • Health(social science)
  • Sociology and Political Science
  • Life-span and Life-course Studies

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