Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset

Laura Marsh, Debra Harris, Kelvin O. Lim, Michael Beal, Anne L. Hoff, Kyungtak Minn, John G. Csernansky, Stacie DeMent, William O. Faustman, Edith V. Sullivan, Adolf Pfefferbaum

Research output: Contribution to journalArticle

Abstract

Background: Early age at onset of schizophrenia often signifies a more severe form of the illness. However, the relationship between age at onset and brain abnormalities has not been established. We assessed temporal- limbic morphometry in severely ill men with chronic schizophrenia who had a relatively early onset of illness and examined the relationships among regional brain volumes, clinical symptoms, and age at illness onset. Method: Temporal lobe, superior temporal gyrus, hippocampus, temporal horn, lateral ventricles, third ventricle, and frontoparietal volumes were measured on magnetic resonance imaging data from 56 schizophrenic men (mean [SD] age at illness onset, 16.6 [4.2] years) recruited from a state hospital and 52 age- and range-matched healthy control men. Results: Patients had significantly smaller gray matter volumes in the temporal lobe, superior temporal gyrus, and frontoparietal regions; smaller temporal lobe white matter volumes; and larger cerebrospinal fluid volumes for temporal lobe sulci and the 3 ventricular measures. There were no group differences in hippocampal volumes. Psychotic symptom subscores from the Brief Psychiatric Rating Scale were selectively correlated with smaller left posterior superior temporal gyrus gray matter volumes. None of the brain measurements were significantly correlated with age at illness onset. Conclusions: Data from this unique sample of severely ill schizophrenic men emphasize a pattern of structural abnormalities involving the cortex, but not the hippocampus, in schizophrenia. Furthermore, these data support theories suggesting that superior temporal gyrus abnormalities contribute selectively to psychotic symptoms and that the extent of structural abnormalities is unrelated to age of clinical symptom onset.

Original languageEnglish (US)
Pages (from-to)1104-1112
Number of pages9
JournalArchives of General Psychiatry
Volume54
Issue number12
StatePublished - 1997
Externally publishedYes

Fingerprint

Temporal Lobe
Age of Onset
Schizophrenia
Magnetic Resonance Imaging
Brain
Brief Psychiatric Rating Scale
Parahippocampal Gyrus
State Hospitals
Third Ventricle
Cerebrospinal Fluid
Hippocampus

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Marsh, L., Harris, D., Lim, K. O., Beal, M., Hoff, A. L., Minn, K., ... Pfefferbaum, A. (1997). Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset. Archives of General Psychiatry, 54(12), 1104-1112.

Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset. / Marsh, Laura; Harris, Debra; Lim, Kelvin O.; Beal, Michael; Hoff, Anne L.; Minn, Kyungtak; Csernansky, John G.; DeMent, Stacie; Faustman, William O.; Sullivan, Edith V.; Pfefferbaum, Adolf.

In: Archives of General Psychiatry, Vol. 54, No. 12, 1997, p. 1104-1112.

Research output: Contribution to journalArticle

Marsh, L, Harris, D, Lim, KO, Beal, M, Hoff, AL, Minn, K, Csernansky, JG, DeMent, S, Faustman, WO, Sullivan, EV & Pfefferbaum, A 1997, 'Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset', Archives of General Psychiatry, vol. 54, no. 12, pp. 1104-1112.
Marsh, Laura ; Harris, Debra ; Lim, Kelvin O. ; Beal, Michael ; Hoff, Anne L. ; Minn, Kyungtak ; Csernansky, John G. ; DeMent, Stacie ; Faustman, William O. ; Sullivan, Edith V. ; Pfefferbaum, Adolf. / Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset. In: Archives of General Psychiatry. 1997 ; Vol. 54, No. 12. pp. 1104-1112.
@article{364f0acb92bd49919eb4ea150146982c,
title = "Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset",
abstract = "Background: Early age at onset of schizophrenia often signifies a more severe form of the illness. However, the relationship between age at onset and brain abnormalities has not been established. We assessed temporal- limbic morphometry in severely ill men with chronic schizophrenia who had a relatively early onset of illness and examined the relationships among regional brain volumes, clinical symptoms, and age at illness onset. Method: Temporal lobe, superior temporal gyrus, hippocampus, temporal horn, lateral ventricles, third ventricle, and frontoparietal volumes were measured on magnetic resonance imaging data from 56 schizophrenic men (mean [SD] age at illness onset, 16.6 [4.2] years) recruited from a state hospital and 52 age- and range-matched healthy control men. Results: Patients had significantly smaller gray matter volumes in the temporal lobe, superior temporal gyrus, and frontoparietal regions; smaller temporal lobe white matter volumes; and larger cerebrospinal fluid volumes for temporal lobe sulci and the 3 ventricular measures. There were no group differences in hippocampal volumes. Psychotic symptom subscores from the Brief Psychiatric Rating Scale were selectively correlated with smaller left posterior superior temporal gyrus gray matter volumes. None of the brain measurements were significantly correlated with age at illness onset. Conclusions: Data from this unique sample of severely ill schizophrenic men emphasize a pattern of structural abnormalities involving the cortex, but not the hippocampus, in schizophrenia. Furthermore, these data support theories suggesting that superior temporal gyrus abnormalities contribute selectively to psychotic symptoms and that the extent of structural abnormalities is unrelated to age of clinical symptom onset.",
author = "Laura Marsh and Debra Harris and Lim, {Kelvin O.} and Michael Beal and Hoff, {Anne L.} and Kyungtak Minn and Csernansky, {John G.} and Stacie DeMent and Faustman, {William O.} and Sullivan, {Edith V.} and Adolf Pfefferbaum",
year = "1997",
language = "English (US)",
volume = "54",
pages = "1104--1112",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - Structural magnetic resonance imaging abnormalities in men with severe chronic schizophrenia and an early age at clinical onset

AU - Marsh, Laura

AU - Harris, Debra

AU - Lim, Kelvin O.

AU - Beal, Michael

AU - Hoff, Anne L.

AU - Minn, Kyungtak

AU - Csernansky, John G.

AU - DeMent, Stacie

AU - Faustman, William O.

AU - Sullivan, Edith V.

AU - Pfefferbaum, Adolf

PY - 1997

Y1 - 1997

N2 - Background: Early age at onset of schizophrenia often signifies a more severe form of the illness. However, the relationship between age at onset and brain abnormalities has not been established. We assessed temporal- limbic morphometry in severely ill men with chronic schizophrenia who had a relatively early onset of illness and examined the relationships among regional brain volumes, clinical symptoms, and age at illness onset. Method: Temporal lobe, superior temporal gyrus, hippocampus, temporal horn, lateral ventricles, third ventricle, and frontoparietal volumes were measured on magnetic resonance imaging data from 56 schizophrenic men (mean [SD] age at illness onset, 16.6 [4.2] years) recruited from a state hospital and 52 age- and range-matched healthy control men. Results: Patients had significantly smaller gray matter volumes in the temporal lobe, superior temporal gyrus, and frontoparietal regions; smaller temporal lobe white matter volumes; and larger cerebrospinal fluid volumes for temporal lobe sulci and the 3 ventricular measures. There were no group differences in hippocampal volumes. Psychotic symptom subscores from the Brief Psychiatric Rating Scale were selectively correlated with smaller left posterior superior temporal gyrus gray matter volumes. None of the brain measurements were significantly correlated with age at illness onset. Conclusions: Data from this unique sample of severely ill schizophrenic men emphasize a pattern of structural abnormalities involving the cortex, but not the hippocampus, in schizophrenia. Furthermore, these data support theories suggesting that superior temporal gyrus abnormalities contribute selectively to psychotic symptoms and that the extent of structural abnormalities is unrelated to age of clinical symptom onset.

AB - Background: Early age at onset of schizophrenia often signifies a more severe form of the illness. However, the relationship between age at onset and brain abnormalities has not been established. We assessed temporal- limbic morphometry in severely ill men with chronic schizophrenia who had a relatively early onset of illness and examined the relationships among regional brain volumes, clinical symptoms, and age at illness onset. Method: Temporal lobe, superior temporal gyrus, hippocampus, temporal horn, lateral ventricles, third ventricle, and frontoparietal volumes were measured on magnetic resonance imaging data from 56 schizophrenic men (mean [SD] age at illness onset, 16.6 [4.2] years) recruited from a state hospital and 52 age- and range-matched healthy control men. Results: Patients had significantly smaller gray matter volumes in the temporal lobe, superior temporal gyrus, and frontoparietal regions; smaller temporal lobe white matter volumes; and larger cerebrospinal fluid volumes for temporal lobe sulci and the 3 ventricular measures. There were no group differences in hippocampal volumes. Psychotic symptom subscores from the Brief Psychiatric Rating Scale were selectively correlated with smaller left posterior superior temporal gyrus gray matter volumes. None of the brain measurements were significantly correlated with age at illness onset. Conclusions: Data from this unique sample of severely ill schizophrenic men emphasize a pattern of structural abnormalities involving the cortex, but not the hippocampus, in schizophrenia. Furthermore, these data support theories suggesting that superior temporal gyrus abnormalities contribute selectively to psychotic symptoms and that the extent of structural abnormalities is unrelated to age of clinical symptom onset.

UR - http://www.scopus.com/inward/record.url?scp=15444343362&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15444343362&partnerID=8YFLogxK

M3 - Article

VL - 54

SP - 1104

EP - 1112

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 12

ER -