Structural insights into regulation and action of SWI2/SNF2 ATPases

Glenn Hauk; Gregory D. Bowman

doi:10.1016/j.sbi.2011.09.003

Structural insights into regulation and action of SWI2/SNF2 ATPases

Glenn Hauk, Gregory D. Bowman

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.

Original language	English (US)
Pages (from-to)	719-727
Number of pages	9
Journal	Current Opinion in Structural Biology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.sbi.2011.09.003
State	Published - Dec 2011
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.sbi.2011.09.003

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title = "Structural insights into regulation and action of SWI2/SNF2 ATPases",

abstract = "This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.",

author = "Glenn Hauk and Bowman, {Gregory D.}",

note = "Funding Information: We thank Ilana Nodelman and other members of the Bowman lab for critical comments and discussions. This work was supported by a grant from the National Institutes of Health ( R01 GM084129 ).",

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AU - Bowman, Gregory D.

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PY - 2011/12

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N2 - This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.

AB - This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.

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Structural insights into regulation and action of SWI2/SNF2 ATPases

Abstract

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