Structural insights into regulation and action of SWI2/SNF2 ATPases

Glenn Hauk, Gregory D. Bowman

Research output: Contribution to journalReview article

Abstract

This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.

Original languageEnglish (US)
Pages (from-to)719-727
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume21
Issue number6
DOIs
StatePublished - Dec 1 2011

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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