Structural immunology of costimualtory and coinhibitory molecules

Sheng Dian Wang, Lie Ping Chen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The T cell costimulatory pathways are central to regulating immune responses, and targeting these pathways represents one of the most promising approaches for achieving immunotherapy. The molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity, affinity, oligomeric state, and valency, which provided the bases for better manipulation of these signaling pathways. The incredible growth of this field led to identification of new members and unexpected interactions, revealing a complicated regulatory network of immune responses. The advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalScience China Life Sciences
Issue number2
StatePublished - Mar 2010


  • Costimulatory molecules
  • Immunotherapy
  • Molecular structure
  • T cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)


Dive into the research topics of 'Structural immunology of costimualtory and coinhibitory molecules'. Together they form a unique fingerprint.

Cite this