Structural immunology of costimualtory and coinhibitory molecules

Sheng Dian Wang, Lie Ping Chen

Research output: Contribution to journalArticle

Abstract

The T cell costimulatory pathways are central to regulating immune responses, and targeting these pathways represents one of the most promising approaches for achieving immunotherapy. The molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity, affinity, oligomeric state, and valency, which provided the bases for better manipulation of these signaling pathways. The incredible growth of this field led to identification of new members and unexpected interactions, revealing a complicated regulatory network of immune responses. The advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalScience China Life Sciences
Volume53
Issue number2
DOIs
StatePublished - Mar 2010

Fingerprint

Immunology
T-cells
Allergy and Immunology
immune response
immunology
T-lymphocytes
T-Lymphocytes
Molecules
immunotherapy
Molecular Structure
chemical structure
Immunotherapy
Molecular structure
ligand
targeting
Ligands
Biological Sciences
therapeutics
receptors
Growth

Keywords

  • Costimulatory molecules
  • Immunotherapy
  • Molecular structure
  • T cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Structural immunology of costimualtory and coinhibitory molecules. / Wang, Sheng Dian; Chen, Lie Ping.

In: Science China Life Sciences, Vol. 53, No. 2, 03.2010, p. 183-189.

Research output: Contribution to journalArticle

Wang, Sheng Dian ; Chen, Lie Ping. / Structural immunology of costimualtory and coinhibitory molecules. In: Science China Life Sciences. 2010 ; Vol. 53, No. 2. pp. 183-189.
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