Structural imaging in premanifest and manifest Huntington disease

Rachael I. Scahill, Ralph Andre, Sarah J. Tabrizi, Elizabeth H. Aylward

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Huntington disease (HD) neuropathology has a devastating effect on brain structure and consequently brain function; neuroimaging provides a means to assess these effects in gene carriers. In this chapter we first outline the unique utility of structural imaging in understanding HD and discuss some of the acquisition and analysis techniques currently available. We review the existing literature to summarize what we know so far about structural brain changes across the spectrum of disease from premanifest through to manifest disease. We then consider how these neuroimaging findings relate to patient function and nonimaging biomarkers, and can be used to predict disease onset. Finally we review the utility of imaging measures for assessment of treatment efficacy in clinical trials.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages247-261
Number of pages15
Volume144
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Publication series

NameHandbook of Clinical Neurology
Volume144
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152

Keywords

  • biomarker
  • cortex
  • Huntington disease
  • MRI
  • striatum
  • volumetric
  • white matter

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Scahill, R. I., Andre, R., Tabrizi, S. J., & Aylward, E. H. (2017). Structural imaging in premanifest and manifest Huntington disease. In Handbook of Clinical Neurology (Vol. 144, pp. 247-261). (Handbook of Clinical Neurology; Vol. 144). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-801893-4.00020-1