Abstract
A model of left ventricular function is developed based on morphological characteristics of the myocardial tissue. The passive response of the three-dimensional collagen network and the active contribution of the muscle fibers are integrated to yield the overall response of the left ventricle which is considered to be a thick wall cylinder. The deformation field and the distributions of stress and pressure are determined at each point in the cardiac cycle by numerically solving three equations of equilibrium. Simulated results in terms of the ventricular deformation during ejection and isovolumic cycles are shown to be in good qualitative agreement with experimental data. It is shown that the collagen network in the heart has considerable effect on the pressure-volume loops. Additional aspects of the subject are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 342-349 |
| Number of pages | 8 |
| Journal | Journal of Biomechanical Engineering |
| Volume | 111 |
| Issue number | 4 |
| State | Published - Nov 1989 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biomedical Engineering
- Biophysics