Structural evaluation of the prefrontal cortex in schizophrenia

Robert W. Buchanan, Katalin Vladar, Patrick Ernest Barta, Godfrey D. Pearlson

Research output: Contribution to journalArticle

Abstract

Objective: Altered prefrontal cortical function has been repeatedly implicated in the pathophysiology of schizophrenia. Attempts to determine whether this altered function is associated with structural changes in the prefrontal cortex have been hampered by the failure to examine more anatomically and functionally homogeneous regions. The authors have developed a reliable set of anatomical landmarks for subdividing the prefrontal cortex into superior, middle, inferior, and orbital regions, in order to determine whether patients with schizophrenia exhibit selective morphological abnormalities of the prefrontal cortex. Method: Magnetic resonance imaging (MRI) studies were obtained in 24 normal control subjects (14 men and 10 women) and 18 patients with schizophrenia (12 men and six women) by using a high-resolution thin spoiled-gradient recall acquisition in the steady-state protocol. The MRI images were used to determine prefrontal gray matter volumes for the four prefrontal regions and prefrontal total gray and white volumes. Results: Patients with schizophrenia exhibited selective gray matter volume reductions in the right and left inferior prefrontal cortex. There were no significant group differences in the other prefrontal regions. Patients with schizophrenia also exhibited decreased prefrontal total while matter and total volumes; there was no significant difference in prefrontal total gray matter volume. Conclusions: Patients with schizophrenia are characterized by relatively selective reductions in inferior prefrontal cortex gray matter volumes.

Original languageEnglish (US)
Pages (from-to)1049-1055
Number of pages7
JournalAmerican Journal of Psychiatry
Volume155
Issue number8
StatePublished - Aug 1998
Externally publishedYes

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Prefrontal Cortex
Schizophrenia
Magnetic Resonance Imaging
Gray Matter

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Buchanan, R. W., Vladar, K., Barta, P. E., & Pearlson, G. D. (1998). Structural evaluation of the prefrontal cortex in schizophrenia. American Journal of Psychiatry, 155(8), 1049-1055.

Structural evaluation of the prefrontal cortex in schizophrenia. / Buchanan, Robert W.; Vladar, Katalin; Barta, Patrick Ernest; Pearlson, Godfrey D.

In: American Journal of Psychiatry, Vol. 155, No. 8, 08.1998, p. 1049-1055.

Research output: Contribution to journalArticle

Buchanan, RW, Vladar, K, Barta, PE & Pearlson, GD 1998, 'Structural evaluation of the prefrontal cortex in schizophrenia', American Journal of Psychiatry, vol. 155, no. 8, pp. 1049-1055.
Buchanan, Robert W. ; Vladar, Katalin ; Barta, Patrick Ernest ; Pearlson, Godfrey D. / Structural evaluation of the prefrontal cortex in schizophrenia. In: American Journal of Psychiatry. 1998 ; Vol. 155, No. 8. pp. 1049-1055.
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