@article{d8997ffcb28f4fe0b3ccc1ea01357e98,
title = "Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires",
abstract = "By studying the processing of pri-miR-9 family, Bofill-De Ros et al. demonstrate that the tertiary structure of pri-miRNA triggers alternative biogenesis. Drosha cleaves pri-miR-9-1 at an additional site because of its distorted and flexible lower stem, generating a 5′ isomiR that regulates a distinct set of genes in low-grade glioma.",
keywords = "Drosha, RNA structure, isomiRs, miR-9, microprocessor, paralogs, primary miRNA",
author = "{Bofill-De Ros}, Xavier and Kasprzak, {Wojciech K.} and Yuba Bhandari and Lixin Fan and Quinn Cavanaugh and Minjie Jiang and Lisheng Dai and Acong Yang and Shao, {Tie Juan} and Shapiro, {Bruce A.} and Wang, {Yun Xing} and Shuo Gu",
note = "Funding Information: We thank Drs. Sandra L. Wolin and Donald L. Court for their critical reading of the manuscript and helpful discussions. For the SAXS experiments, we thank the SAXS Core facility of the National Cancer Institute. The SAXS data were collected at beamline under the PUP-24152 agreement with the Argonne National Laboratory. This work was funded by the intramural research program of the National Cancer Institute . This project was funded in part with federal funds from the Frederick National Laboratory for Cancer Research , NIH , under contract HHSN261200800001E , for W.K.K. Funding Information: We thank Drs. Sandra L. Wolin and Donald L. Court for their critical reading of the manuscript and helpful discussions. For the SAXS experiments, we thank the SAXS Core facility of the National Cancer Institute. The SAXS data were collected at beamline under the PUP-24152 agreement with the Argonne National Laboratory. This work was funded by the intramural research program of the National Cancer Institute. This project was funded in part with federal funds from the Frederick National Laboratory for Cancer Research, NIH, under contract HHSN261200800001E, for W.K.K. Publisher Copyright: {\textcopyright} 2018",
year = "2019",
month = jan,
day = "8",
doi = "10.1016/j.celrep.2018.12.054",
language = "English (US)",
volume = "26",
pages = "447--459.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}