Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie Juan Shao, Bruce A. Shapiro, Yun Xing Wang, Shuo Gu

Research output: Contribution to journalArticlepeer-review

Abstract

By studying the processing of pri-miR-9 family, Bofill-De Ros et al. demonstrate that the tertiary structure of pri-miRNA triggers alternative biogenesis. Drosha cleaves pri-miR-9-1 at an additional site because of its distorted and flexible lower stem, generating a 5′ isomiR that regulates a distinct set of genes in low-grade glioma.

Original languageEnglish (US)
Pages (from-to)447-459.e4
JournalCell Reports
Volume26
Issue number2
DOIs
StatePublished - Jan 8 2019
Externally publishedYes

Keywords

  • Drosha
  • RNA structure
  • isomiRs
  • miR-9
  • microprocessor
  • paralogs
  • primary miRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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