Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Xavier Bofill-De Ros; Wojciech K. Kasprzak; Yuba Bhandari; Lixin Fan; Quinn Cavanaugh; Minjie Jiang; Lisheng Dai; Acong Yang; Tie Juan Shao; Bruce A. Shapiro; Yun Xing Wang; Shuo Gu

doi:10.1016/j.celrep.2018.12.054

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie Juan Shao, Bruce A. Shapiro, Yun Xing Wang, Shuo Gu

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

By studying the processing of pri-miR-9 family, Bofill-De Ros et al. demonstrate that the tertiary structure of pri-miRNA triggers alternative biogenesis. Drosha cleaves pri-miR-9-1 at an additional site because of its distorted and flexible lower stem, generating a 5′ isomiR that regulates a distinct set of genes in low-grade glioma.

Original language	English (US)
Pages (from-to)	447-459.e4
Journal	Cell Reports
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2018.12.054
State	Published - Jan 8 2019
Externally published	Yes

Keywords

Drosha
RNA structure
isomiRs
miR-9
microprocessor
paralogs
primary miRNA

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2018.12.054

Cite this

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title = "Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires",

abstract = "By studying the processing of pri-miR-9 family, Bofill-De Ros et al. demonstrate that the tertiary structure of pri-miRNA triggers alternative biogenesis. Drosha cleaves pri-miR-9-1 at an additional site because of its distorted and flexible lower stem, generating a 5′ isomiR that regulates a distinct set of genes in low-grade glioma.",

keywords = "Drosha, RNA structure, isomiRs, miR-9, microprocessor, paralogs, primary miRNA",

author = "{Bofill-De Ros}, Xavier and Kasprzak, {Wojciech K.} and Yuba Bhandari and Lixin Fan and Quinn Cavanaugh and Minjie Jiang and Lisheng Dai and Acong Yang and Shao, {Tie Juan} and Shapiro, {Bruce A.} and Wang, {Yun Xing} and Shuo Gu",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = jan,

day = "8",

doi = "10.1016/j.celrep.2018.12.054",

language = "English (US)",

volume = "26",

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journal = "Cell Reports",

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TY - JOUR

T1 - Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

AU - Bofill-De Ros, Xavier

AU - Kasprzak, Wojciech K.

AU - Bhandari, Yuba

AU - Fan, Lixin

AU - Cavanaugh, Quinn

AU - Jiang, Minjie

AU - Dai, Lisheng

AU - Yang, Acong

AU - Shao, Tie Juan

AU - Shapiro, Bruce A.

AU - Wang, Yun Xing

AU - Gu, Shuo

PY - 2019/1/8

Y1 - 2019/1/8

N2 - By studying the processing of pri-miR-9 family, Bofill-De Ros et al. demonstrate that the tertiary structure of pri-miRNA triggers alternative biogenesis. Drosha cleaves pri-miR-9-1 at an additional site because of its distorted and flexible lower stem, generating a 5′ isomiR that regulates a distinct set of genes in low-grade glioma.

AB - By studying the processing of pri-miR-9 family, Bofill-De Ros et al. demonstrate that the tertiary structure of pri-miRNA triggers alternative biogenesis. Drosha cleaves pri-miR-9-1 at an additional site because of its distorted and flexible lower stem, generating a 5′ isomiR that regulates a distinct set of genes in low-grade glioma.

KW - Drosha

KW - RNA structure

KW - isomiRs

KW - miR-9

KW - microprocessor

KW - paralogs

KW - primary miRNA

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DO - 10.1016/j.celrep.2018.12.054

M3 - Article

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AN - SCOPUS:85058716199

SN - 2211-1247

VL - 26

SP - 447-459.e4

JO - Cell Reports

JF - Cell Reports

IS - 2

ER -

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Abstract

Keywords

ASJC Scopus subject areas

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