Structural correlates of renal electrolyte alterations in acute renal failure.

L. C. Racusen

Research output: Contribution to journalReview article

Abstract

In this review, structural and ultrastructural alterations in the kidney in acute renal failure are described and illustrated in some detail. Morphologic findings in clinical and experimental acute renal failure of the type produced by ischemia and some nephrotoxins, so-called 'acute tubular necrosis' are compared and discrepancies between findings in clinical specimens and experimental models noted and discussed. Since perturbations in intrarenal electrolyte species almost surely play a major pathogenic role in renal injury and dysfunction, correlations between altered intrarenal electrolyte transport and abnormal cellular ion concentrations, and morphologic alterations are emphasized in this review.

Original languageEnglish (US)
Pages (from-to)72-88
Number of pages17
JournalMineral and Electrolyte Metabolism
Volume17
Issue number2
StatePublished - Dec 1 1991

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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