Structural comparisons of class I phosphoinositide 3-kinases

L. Mario Amzel, Chuan Hsiang Huang, Diana Mandelker, Christoph Lengauer, Sandra B. Gabelli, Bert Vogelstein

Research output: Contribution to journalReview article

Abstract

Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell growth. One of these kinases, PI3Kα, is frequently mutated in diverse tumour types. The recently determined structure of PI3Kα reveals features that distinguish this enzyme from related lipid kinases. In addition, wild-type PI3Kγ differs from PI3Kα by a substitution identical to a PI3Kα oncogenic mutant (His1047Arg) that might explain the differences in the enzymatic activities of the normal and mutant PI3Kα. Comparison of the PI3K structures also identified structural features that could potentially be exploited for the design of isoform-specific inhibitors.

Original languageEnglish (US)
Pages (from-to)665-669
Number of pages5
JournalNature Reviews Cancer
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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