Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

Frank H. Bellevue, Michelle Boahbedason, Ronghui Wu, Patrick M. Woster, Robert A Casero, Donna Rattendi, Schennella Lane, Cyrus J. Bacchi

Research output: Contribution to journalArticle

Abstract

A series of symmetrically or unsymmetrically alkyl-substituted polyamine analogues were synthesized containing either a 3-3-3 or 3-7-3 polyamine backbone. These analogues were evaluated in vitro as antitumor agents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as antitrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data suggest that it is possible to specifically target tumor cells or parasitic organisms with alkylpolyamine analogues based on structure.

Original languageEnglish (US)
Pages (from-to)2765-2770
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number22
DOIs
StatePublished - Nov 19 1996

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Antiparasitic Agents
Polyamines
Trypanosoma brucei rhodesiense
Cells
Trypanosoma brucei brucei
Antineoplastic Agents
Tumors
Carcinoma
Cell Line
Lung
Neoplasms
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity. / Bellevue, Frank H.; Boahbedason, Michelle; Wu, Ronghui; Woster, Patrick M.; Casero, Robert A; Rattendi, Donna; Lane, Schennella; Bacchi, Cyrus J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 22, 19.11.1996, p. 2765-2770.

Research output: Contribution to journalArticle

Bellevue, Frank H. ; Boahbedason, Michelle ; Wu, Ronghui ; Woster, Patrick M. ; Casero, Robert A ; Rattendi, Donna ; Lane, Schennella ; Bacchi, Cyrus J. / Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 22. pp. 2765-2770.
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