Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

Frank H. Bellevue, Michelle Boahbedason, Ronghui Wu, Patrick M. Woster, Robert A. Casero, Donna Rattendi, Schennella Lane, Cyrus J. Bacchi

Research output: Contribution to journalArticlepeer-review

Abstract

A series of symmetrically or unsymmetrically alkyl-substituted polyamine analogues were synthesized containing either a 3-3-3 or 3-7-3 polyamine backbone. These analogues were evaluated in vitro as antitumor agents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as antitrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data suggest that it is possible to specifically target tumor cells or parasitic organisms with alkylpolyamine analogues based on structure.

Original languageEnglish (US)
Pages (from-to)2765-2770
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number22
DOIs
StatePublished - Nov 19 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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