Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells

Thomas Klonisch, Aleksandra Glogowska, Thatchawan Thanasupawat, Maxwell Burg, Jerry Krcek, Marshall Pitz, Appalaraju Jaggupilli, Prashen Chelikani, Guang William Wong, Sabine Hombach-Klonisch

Research output: Contribution to journalArticle

Abstract

We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors.

Original languageEnglish (US)
JournalBritish Journal of Pharmacology
DOIs
StateAccepted/In press - 2016

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells'. Together they form a unique fingerprint.

  • Cite this