Structural characteristics of retinal layers adjacent to geographic atrophy

Mohammad A. Sadiq; Mostafa Hanout; Salman Sarwar; Nithya Rajagopalan; Jose R. Maya; Liz J. Zapata; Diana V. Do; Quan D. Nguyen; Yasir J. Sepah

doi:10.3928/23258160-20151008-03

Structural characteristics of retinal layers adjacent to geographic atrophy

Mohammad A. Sadiq, Mostafa Hanout, Salman Sarwar, Nithya Rajagopalan, Jose R. Maya, Liz J. Zapata, Diana V. Do, Quan D. Nguyen, Yasir J. Sepah

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background and Objective: To compare the anatomy of different retinal layers adjacent to areas of geographic atrophy (GA) to those of eyes with no known ocular diseases. Patients and Methods: Spectral-domain optical coherence tomography (SD-OCT) scans from eyes with GA were retrospectively reviewed. Two scans with no findings suggestive of GA changes on OCT were selected from immediately above and/or below the edge of the lesions. Thickness values of the retinal layers were calculated and compared to values obtained from normal subjects. Results: Forty-four eyes (30 patients) were compared to 20 healthy eyes. Retinal pigment epithelium (RPE), inner nuclear layer (INL), and full retinal thickness (FRT) values were significantly lower in patients compared to healthy subjects. Thicknesses of all other layers were not significantly different. Conclusion: Clinically appearing, non-involved RPE and INL layers of eyes with GA demonstrate significant thinning compared to corresponding layers in eyes with no known ocular diseases.

Original language	English (US)
Pages (from-to)	914-919
Number of pages	6
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	46
Issue number	9
DOIs	https://doi.org/10.3928/23258160-20151008-03
State	Published - Oct 2015

ASJC Scopus subject areas

Surgery
Ophthalmology

Access to Document

10.3928/23258160-20151008-03

Cite this

@article{e2f643bacf994b54a62fa3bbaa5c22e0,

title = "Structural characteristics of retinal layers adjacent to geographic atrophy",

abstract = "Background and Objective: To compare the anatomy of different retinal layers adjacent to areas of geographic atrophy (GA) to those of eyes with no known ocular diseases. Patients and Methods: Spectral-domain optical coherence tomography (SD-OCT) scans from eyes with GA were retrospectively reviewed. Two scans with no findings suggestive of GA changes on OCT were selected from immediately above and/or below the edge of the lesions. Thickness values of the retinal layers were calculated and compared to values obtained from normal subjects. Results: Forty-four eyes (30 patients) were compared to 20 healthy eyes. Retinal pigment epithelium (RPE), inner nuclear layer (INL), and full retinal thickness (FRT) values were significantly lower in patients compared to healthy subjects. Thicknesses of all other layers were not significantly different. Conclusion: Clinically appearing, non-involved RPE and INL layers of eyes with GA demonstrate significant thinning compared to corresponding layers in eyes with no known ocular diseases.",

author = "Sadiq, {Mohammad A.} and Mostafa Hanout and Salman Sarwar and Nithya Rajagopalan and Maya, {Jose R.} and Zapata, {Liz J.} and Do, {Diana V.} and Nguyen, {Quan D.} and Sepah, {Yasir J.}",

year = "2015",

month = oct,

doi = "10.3928/23258160-20151008-03",

language = "English (US)",

volume = "46",

pages = "914--919",

journal = "Ophthalmic Surgery Lasers and Imaging Retina",

issn = "2325-8160",

publisher = "Slack Incorporated",

number = "9",

}

TY - JOUR

T1 - Structural characteristics of retinal layers adjacent to geographic atrophy

AU - Sadiq, Mohammad A.

AU - Hanout, Mostafa

AU - Sarwar, Salman

AU - Rajagopalan, Nithya

AU - Maya, Jose R.

AU - Zapata, Liz J.

AU - Do, Diana V.

AU - Nguyen, Quan D.

AU - Sepah, Yasir J.

PY - 2015/10

Y1 - 2015/10

N2 - Background and Objective: To compare the anatomy of different retinal layers adjacent to areas of geographic atrophy (GA) to those of eyes with no known ocular diseases. Patients and Methods: Spectral-domain optical coherence tomography (SD-OCT) scans from eyes with GA were retrospectively reviewed. Two scans with no findings suggestive of GA changes on OCT were selected from immediately above and/or below the edge of the lesions. Thickness values of the retinal layers were calculated and compared to values obtained from normal subjects. Results: Forty-four eyes (30 patients) were compared to 20 healthy eyes. Retinal pigment epithelium (RPE), inner nuclear layer (INL), and full retinal thickness (FRT) values were significantly lower in patients compared to healthy subjects. Thicknesses of all other layers were not significantly different. Conclusion: Clinically appearing, non-involved RPE and INL layers of eyes with GA demonstrate significant thinning compared to corresponding layers in eyes with no known ocular diseases.

AB - Background and Objective: To compare the anatomy of different retinal layers adjacent to areas of geographic atrophy (GA) to those of eyes with no known ocular diseases. Patients and Methods: Spectral-domain optical coherence tomography (SD-OCT) scans from eyes with GA were retrospectively reviewed. Two scans with no findings suggestive of GA changes on OCT were selected from immediately above and/or below the edge of the lesions. Thickness values of the retinal layers were calculated and compared to values obtained from normal subjects. Results: Forty-four eyes (30 patients) were compared to 20 healthy eyes. Retinal pigment epithelium (RPE), inner nuclear layer (INL), and full retinal thickness (FRT) values were significantly lower in patients compared to healthy subjects. Thicknesses of all other layers were not significantly different. Conclusion: Clinically appearing, non-involved RPE and INL layers of eyes with GA demonstrate significant thinning compared to corresponding layers in eyes with no known ocular diseases.

UR - http://www.scopus.com/inward/record.url?scp=84944553956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944553956&partnerID=8YFLogxK

U2 - 10.3928/23258160-20151008-03

DO - 10.3928/23258160-20151008-03

M3 - Article

C2 - 26469230

AN - SCOPUS:84944553956

SN - 2325-8160

VL - 46

SP - 914

EP - 919

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

IS - 9

ER -

Structural characteristics of retinal layers adjacent to geographic atrophy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this