Structural brain pathology in schizophrenia revisited. Prefrontal cortex pathology is inversely correlated with cerebrospinal fluid levels of homovanillic acid

Allen R. Doran; John Boronow; Daniel R. Weinberger; Owen M. Wolkowitz; Alan Breier; David Pickar

doi:10.1016/0893-133X(87)90006-6

Structural brain pathology in schizophrenia revisited. Prefrontal cortex pathology is inversely correlated with cerebrospinal fluid levels of homovanillic acid

Allen R. Doran, John Boronow, Daniel R. Weinberger, Owen M. Wolkowitz, Alan Breier, David Pickar

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Computed tomography scan analysis of 35 schizophrenic patients, 26 medical patients, and 31 normal controls revealed significantly larger ventricular brain ratios and structural changes consistent with cortical atrophy in both schizophrenic and medical patients in comparison with normal controls. The schizophrenic patients, however, differed from both control groups in terms of greater prefrontal cortical markings consistent with prefrontal atrophy, and this finding correlated inversely with levels of cerebrospinal fluid homovanillic acid. Results from this study, in addition to replicating previous findings and addressing methodologic issues concerning controls, provide new evidence implicating abnormality of the prefrontal cortex in schizophrenia and link this abnormality to central nervous system dopaminergic function.

Original language	English (US)
Pages (from-to)	25-32
Number of pages	8
Journal	Neuropsychopharmacology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0893-133X(87)90006-6
State	Published - Dec 1987
Externally published	Yes

Keywords

CT scan
Dopamine
Prefrontal cortex
Schizophrenia

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health

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10.1016/0893-133X(87)90006-6

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AU - Doran, Allen R.

AU - Boronow, John

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AU - Wolkowitz, Owen M.

AU - Breier, Alan

AU - Pickar, David

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AB - Computed tomography scan analysis of 35 schizophrenic patients, 26 medical patients, and 31 normal controls revealed significantly larger ventricular brain ratios and structural changes consistent with cortical atrophy in both schizophrenic and medical patients in comparison with normal controls. The schizophrenic patients, however, differed from both control groups in terms of greater prefrontal cortical markings consistent with prefrontal atrophy, and this finding correlated inversely with levels of cerebrospinal fluid homovanillic acid. Results from this study, in addition to replicating previous findings and addressing methodologic issues concerning controls, provide new evidence implicating abnormality of the prefrontal cortex in schizophrenia and link this abnormality to central nervous system dopaminergic function.

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Structural brain pathology in schizophrenia revisited. Prefrontal cortex pathology is inversely correlated with cerebrospinal fluid levels of homovanillic acid

Abstract

Keywords

ASJC Scopus subject areas

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