Structural brain imaging in schizophrenia: A selective review

Godfrey D. Pearlson, Laura Marsh

    Research output: Contribution to journalArticlepeer-review


    Structural neuroimaging studies have provided some of the most consistent evidence for brain abnormalities in schizophrenia. Since the initial computed tomography study by Johnstone and co-workers, which reported lateral ventricular enlargement in schizophrenia, advances in brain imaging technology have enabled further and more refined characterization of abnormal brain structure in schizophrenia in vivo. This selective review discusses the major issues and findings in structural neuroimaging studies of schizophrenia. Among these are evidence for generalized and regional brain volume abnormalities, the specificity of anatomic findings to schizophrenia and to men versus women with schizophrenia, the contribution of genetic influences, and the timing of neuroanatomic pathology in schizophrenia. The second section reviews new approaches for examining brain structure in schizophrenia and their applications to studies on the pathophysiology of schizophrenia. Copyright (C) 1999 Society of Biological Psychiatry.

    Original languageEnglish (US)
    Pages (from-to)627-649
    Number of pages23
    JournalBiological psychiatry
    Issue number5
    StatePublished - Sep 1 1999


    • Brain
    • Cortex
    • Imaging
    • MRI
    • Schizophrenia
    • Temporal lobe

    ASJC Scopus subject areas

    • Biological Psychiatry

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