TY - JOUR
T1 - Structural brain correlates of emotional disorder in multiple sclerosis
AU - Rabins, Peter V.
AU - Brooks, Benjamin R.
AU - O'donnell, Pat
AU - Pearlson, Godfrey D.
AU - Moberg, Paul
AU - Jubelt, Burk
AU - Coyle, Pat
AU - Dalos, Nancy
AU - Folstein, Marshal F.
N1 - Funding Information:
The authors thank Drs Richard T. Johnson and Arthur A. Siebens for access to patients and Ellen Dees for help with data acquisition. This work was supported in part by the T. Rowe and Eleanor Price Foundation, NIMH Grant 1K07 00505 (P.V.R.) and the Maryland Multiple Sclerosis Society (P.O.).
PY - 1986/8
Y1 - 1986/8
N2 - SUMMARY. Eighty-seven patients with definite multiple sclerosis (MS) were examined neurologically and administered the Mini-mental State examination (MMS) to asses cognitive disability at the beginning and end of a one-year study. A CT scan was performed in 37. A group of 16 patients with stable spinal cord injuries (SCI) were studied in a similar manner. Of the MS patients, 47% had a mean General Health Questionnaire (GHQ) score in the abnormal range. This was a higher rate than in SCI patients (p = 0.004). Mean depression scores were similar in MS and SCI patients, but MS patients with brain involvement were more depressed than those with cord lesions only (p = 0.05). Depression score was unrelated to functional disability but was correlated with the degree of neurological impairment (p = 0.03). Euphoric patients were more likely to have brain involvement (P = 0.006), to have progressive MS (P < 0.0001), and to have enlarged ventricles (P = 0.04) and were more impaired cognitively (P = 0.04) than noneuphoric patients. These results suggest that depression in MS patients is partly determined by the presence of brain involvement, but that it is also an emotional reaction to the disorder Euphoria and cognitive disorder are reflections of brain involvement.
AB - SUMMARY. Eighty-seven patients with definite multiple sclerosis (MS) were examined neurologically and administered the Mini-mental State examination (MMS) to asses cognitive disability at the beginning and end of a one-year study. A CT scan was performed in 37. A group of 16 patients with stable spinal cord injuries (SCI) were studied in a similar manner. Of the MS patients, 47% had a mean General Health Questionnaire (GHQ) score in the abnormal range. This was a higher rate than in SCI patients (p = 0.004). Mean depression scores were similar in MS and SCI patients, but MS patients with brain involvement were more depressed than those with cord lesions only (p = 0.05). Depression score was unrelated to functional disability but was correlated with the degree of neurological impairment (p = 0.03). Euphoric patients were more likely to have brain involvement (P = 0.006), to have progressive MS (P < 0.0001), and to have enlarged ventricles (P = 0.04) and were more impaired cognitively (P = 0.04) than noneuphoric patients. These results suggest that depression in MS patients is partly determined by the presence of brain involvement, but that it is also an emotional reaction to the disorder Euphoria and cognitive disorder are reflections of brain involvement.
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U2 - 10.1093/brain/109.4.585
DO - 10.1093/brain/109.4.585
M3 - Article
C2 - 3730806
AN - SCOPUS:0022519353
SN - 0006-8950
VL - 109
SP - 585
EP - 597
JO - Brain
JF - Brain
IS - 4
ER -