Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis

Laura Marsh, Edith V. Sullivan, Martha Morrell, Kelvin O. Lim, Adolf Pfefferbaum

Research output: Contribution to journalArticle

Abstract

Chronic interictal psychotic syndromes, often resembling schizophrenia, develop in some patients with epilepsy. Although widespread brain abnormalities are recognized as characteristic of schizophrenia, prevailing but controversial hypotheses on the co-occurrence of epilepsy and psychosis implicate left temporal lobe pathology. In this study, quantitative MRI methods were used to address the regional specificity of structural brain abnormalities in patients with epilepsy plus chronic interictal psychosis (E + PSY, n = 9) relative to three comparison groups: unilateral temporal lobe epilepsy without chronic psychosis (TLE, n = 18), schizophrenia (SCZ, n = 46), and healthy control subjects (HC, n = 57). Brain measures, derived from a coronal spin-echo MRI sequence, were adjusted for age and cerebral volume. Relative to HC, all patient groups had ventricular enlargement and smaller temporal lobe, frontoparietal, and superior temporal gyrus gray matter volumes, with the extent of these abnormalities greatest in E + PSY. Only TLE had temporal lobe white matter deficits, as well as smaller hippocampi, which were ipsilateral to the seizure focus. Structural brain abnormalities in E + PSY are not restricted to the left temporal lobe. The confluence of cortical gray matter deficits in E + PSY and SCZ suggests salience to chronic psychosis.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalPsychiatry Research - Neuroimaging
Volume108
Issue number1
DOIs
StatePublished - Nov 5 2001

Fingerprint

Temporal Lobe
Psychotic Disorders
Epilepsy
Schizophrenia
Brain
Temporal Lobe Epilepsy
Hippocampus
Healthy Volunteers
Seizures
Pathology
Gray Matter

Keywords

  • Cortex
  • MRI
  • Seizures
  • Temporal lobe

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis. / Marsh, Laura; Sullivan, Edith V.; Morrell, Martha; Lim, Kelvin O.; Pfefferbaum, Adolf.

In: Psychiatry Research - Neuroimaging, Vol. 108, No. 1, 05.11.2001, p. 1-15.

Research output: Contribution to journalArticle

Marsh, Laura ; Sullivan, Edith V. ; Morrell, Martha ; Lim, Kelvin O. ; Pfefferbaum, Adolf. / Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis. In: Psychiatry Research - Neuroimaging. 2001 ; Vol. 108, No. 1. pp. 1-15.
@article{96b38db54a58420e84dd3bac5727b5e5,
title = "Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis",
abstract = "Chronic interictal psychotic syndromes, often resembling schizophrenia, develop in some patients with epilepsy. Although widespread brain abnormalities are recognized as characteristic of schizophrenia, prevailing but controversial hypotheses on the co-occurrence of epilepsy and psychosis implicate left temporal lobe pathology. In this study, quantitative MRI methods were used to address the regional specificity of structural brain abnormalities in patients with epilepsy plus chronic interictal psychosis (E + PSY, n = 9) relative to three comparison groups: unilateral temporal lobe epilepsy without chronic psychosis (TLE, n = 18), schizophrenia (SCZ, n = 46), and healthy control subjects (HC, n = 57). Brain measures, derived from a coronal spin-echo MRI sequence, were adjusted for age and cerebral volume. Relative to HC, all patient groups had ventricular enlargement and smaller temporal lobe, frontoparietal, and superior temporal gyrus gray matter volumes, with the extent of these abnormalities greatest in E + PSY. Only TLE had temporal lobe white matter deficits, as well as smaller hippocampi, which were ipsilateral to the seizure focus. Structural brain abnormalities in E + PSY are not restricted to the left temporal lobe. The confluence of cortical gray matter deficits in E + PSY and SCZ suggests salience to chronic psychosis.",
keywords = "Cortex, MRI, Seizures, Temporal lobe",
author = "Laura Marsh and Sullivan, {Edith V.} and Martha Morrell and Lim, {Kelvin O.} and Adolf Pfefferbaum",
year = "2001",
month = "11",
day = "5",
doi = "10.1016/S0925-4927(01)00115-9",
language = "English (US)",
volume = "108",
pages = "1--15",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis

AU - Marsh, Laura

AU - Sullivan, Edith V.

AU - Morrell, Martha

AU - Lim, Kelvin O.

AU - Pfefferbaum, Adolf

PY - 2001/11/5

Y1 - 2001/11/5

N2 - Chronic interictal psychotic syndromes, often resembling schizophrenia, develop in some patients with epilepsy. Although widespread brain abnormalities are recognized as characteristic of schizophrenia, prevailing but controversial hypotheses on the co-occurrence of epilepsy and psychosis implicate left temporal lobe pathology. In this study, quantitative MRI methods were used to address the regional specificity of structural brain abnormalities in patients with epilepsy plus chronic interictal psychosis (E + PSY, n = 9) relative to three comparison groups: unilateral temporal lobe epilepsy without chronic psychosis (TLE, n = 18), schizophrenia (SCZ, n = 46), and healthy control subjects (HC, n = 57). Brain measures, derived from a coronal spin-echo MRI sequence, were adjusted for age and cerebral volume. Relative to HC, all patient groups had ventricular enlargement and smaller temporal lobe, frontoparietal, and superior temporal gyrus gray matter volumes, with the extent of these abnormalities greatest in E + PSY. Only TLE had temporal lobe white matter deficits, as well as smaller hippocampi, which were ipsilateral to the seizure focus. Structural brain abnormalities in E + PSY are not restricted to the left temporal lobe. The confluence of cortical gray matter deficits in E + PSY and SCZ suggests salience to chronic psychosis.

AB - Chronic interictal psychotic syndromes, often resembling schizophrenia, develop in some patients with epilepsy. Although widespread brain abnormalities are recognized as characteristic of schizophrenia, prevailing but controversial hypotheses on the co-occurrence of epilepsy and psychosis implicate left temporal lobe pathology. In this study, quantitative MRI methods were used to address the regional specificity of structural brain abnormalities in patients with epilepsy plus chronic interictal psychosis (E + PSY, n = 9) relative to three comparison groups: unilateral temporal lobe epilepsy without chronic psychosis (TLE, n = 18), schizophrenia (SCZ, n = 46), and healthy control subjects (HC, n = 57). Brain measures, derived from a coronal spin-echo MRI sequence, were adjusted for age and cerebral volume. Relative to HC, all patient groups had ventricular enlargement and smaller temporal lobe, frontoparietal, and superior temporal gyrus gray matter volumes, with the extent of these abnormalities greatest in E + PSY. Only TLE had temporal lobe white matter deficits, as well as smaller hippocampi, which were ipsilateral to the seizure focus. Structural brain abnormalities in E + PSY are not restricted to the left temporal lobe. The confluence of cortical gray matter deficits in E + PSY and SCZ suggests salience to chronic psychosis.

KW - Cortex

KW - MRI

KW - Seizures

KW - Temporal lobe

UR - http://www.scopus.com/inward/record.url?scp=0035813397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035813397&partnerID=8YFLogxK

U2 - 10.1016/S0925-4927(01)00115-9

DO - 10.1016/S0925-4927(01)00115-9

M3 - Article

C2 - 11677063

AN - SCOPUS:0035813397

VL - 108

SP - 1

EP - 15

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 1

ER -