Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity

Wei Li, Yongjun Dang, Jun Liu, Biao Yu

Research output: Contribution to journalArticle

Abstract

Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity.

Original languageEnglish (US)
Pages (from-to)3112-3115
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number10
DOIs
StatePublished - May 15 2010

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Cell proliferation
Structure-Activity Relationship
Biological Products
Tumors
Neoplasms
Cells
Cell Proliferation
Cell Line
spiroketal
hippuristanol

Keywords

  • Cancer
  • Eukaryotic translation initiation
  • Inhibitor

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity. / Li, Wei; Dang, Yongjun; Liu, Jun; Yu, Biao.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 10, 15.05.2010, p. 3112-3115.

Research output: Contribution to journalArticle

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