Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes

Edward C. Twomey, Maria V. Yelshanskaya, Alexander I. Sobolevsky

Research output: Contribution to journalReview articlepeer-review

Abstract

Fast excitatory neurotransmission is mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of ionotropic glutamate receptor (AMPAR). AMPARs initiate depolarization of the postsynaptic neuron by allowing cations to enter through their ion channel pores in response to binding of the neurotransmitter glutamate. AMPAR function is dramatically affected by auxiliary subunits, which are regulatory proteins that form various complexes with AMPARs throughout the brain. The most well-studied auxiliary subunits are the transmembrane AMPAR regulatory proteins (TARPs), which alter the assembly, trafficking, localization, kinetics, and pharmacology of AMPARs. Recent structural and functional studies of TARPs and the TARP-fold germ cell-specific gene 1-like (GSG1L) subunit have provided important glimpses into how auxiliary subunits regulate the function of synaptic complexes. In this review, we put these recent structures in the context of new functional findings in order to gain insight into the determinants of AMPAR regulation by TARPs. We thus reveal why TARPs display a broad range of effects despite their conserved modular architecture.

Original languageEnglish (US)
Pages (from-to)1347-1356
Number of pages10
JournalJournal of General Physiology
Volume151
Issue number12
DOIs
StatePublished - Dec 2 2019
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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