@inproceedings{5c95262f70fb4e0ab8970494326ccbaf,
title = "Structural and functional genetic disorders of the great vessels and outflow tracts",
abstract = "Development of the aorta and pulmonary artery is a complex process involving multiple molecular genetic pathways that modulate morphogenesis of the outflow tracts and the anastomosis of branch vessels. Recent genetic studies of the cardiovascular system demonstrate that congenital and adult onset progressive disorders of the great vessels such as aneurysms are components of generalized vascular, cardiac, and extracardiovascular syndromes. Current paradigms suggest that aortic disease is founded in patterning anomalies of the conotruncus that occur in utero. These aberrations can be consequences of genetic aberrations in transcriptional regulation of signal transduction both within and outside the developing great vessels.",
keywords = "Aneurysm, Conotruncus, Genetic, Great vessels, In utero, Signal transduction",
author = "Bee, {Katharine J.} and David Wilkes and Devereux, {Richard B.} and Lerman, {Bruce B.} and Dietz, {Harry C.} and Basson, {Craig T.}",
year = "2006",
month = nov,
doi = "10.1196/annals.1383.002",
language = "English (US)",
isbn = "1573316571",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "256--269",
booktitle = "The Abdominal Aortic Aneurysm",
}