TY - JOUR
T1 - Structural and functional brain changes in bipolar disorder
T2 - A selective review
AU - Pearlson, Godfrey D.
N1 - Funding Information:
Acknowledgments to NIMH grants MH 43775, 43326, and 52886 and AG11859 and to the Outpatient General Clinical Research Center, RR 00722 to Dr Pearlson, and to the Stanley Foundation for support and the generous loan of post-mortem brain tissue.
PY - 1999/9/29
Y1 - 1999/9/29
N2 - The purpose of this paper is to provide a concise, selective review of the major issues and findings germane to structural and functional neuroimaging studies of bipolar affective disorder (BPD). In attempting to identify the brain changes associated with BPD, investigators have used neuroimaging techniques to focus on several interrelated questions. These are: What are the changes and where do they occur? Do their nature and location suggest a particular etiopathologic basis or have notable clinical correlates? With regard to specificity, are the changes unique to BPD, or do they overlap with those reported in other neuropsychiatric illnesses, especially schizophrenia? Do they occur in brain systems that normally play a role in modulating mood? Finally, how do the brain changes integrate with neurocognitive, neurogenetic, and neuropathologic data in the same patients? To date, these questions have been addressed only preliminarily. We outline some of the strategies used to pursue answers to these questions and review conclusions to date. (C) 1999 Elsevier Science B.V. All rights reserved.
AB - The purpose of this paper is to provide a concise, selective review of the major issues and findings germane to structural and functional neuroimaging studies of bipolar affective disorder (BPD). In attempting to identify the brain changes associated with BPD, investigators have used neuroimaging techniques to focus on several interrelated questions. These are: What are the changes and where do they occur? Do their nature and location suggest a particular etiopathologic basis or have notable clinical correlates? With regard to specificity, are the changes unique to BPD, or do they overlap with those reported in other neuropsychiatric illnesses, especially schizophrenia? Do they occur in brain systems that normally play a role in modulating mood? Finally, how do the brain changes integrate with neurocognitive, neurogenetic, and neuropathologic data in the same patients? To date, these questions have been addressed only preliminarily. We outline some of the strategies used to pursue answers to these questions and review conclusions to date. (C) 1999 Elsevier Science B.V. All rights reserved.
KW - Bipolar disorder
KW - Neuroimaging
KW - Review
KW - Structural and functional brain change
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U2 - 10.1016/S0920-9964(99)00112-7
DO - 10.1016/S0920-9964(99)00112-7
M3 - Article
C2 - 10507524
AN - SCOPUS:0032871977
SN - 0920-9964
VL - 39
SP - 133
EP - 140
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2
ER -