Structural and biochemical alterations in canine venous autografts

Richard M. Larson, Richard L. McCann, Per Otto Hagen, James C.A. Fuchs, James S. Mitchener

Research output: Contribution to journalArticlepeer-review


This paper describes morphological alterations and quantifies the changes in lipid concentration and composition which occur in veins transplanted into the arterial system. Under normolipidemic conditions, intimal proliferation occurs in the vein grafts with no significant alteration in the lipid concentration. Under hypercholesterolemic conditions intimal proliferation as well as the accumulation of substantial quantities of lipids occur in these grafts. The extent of the lipid accumulation in the vein grafts was considerably larger than in the arteries.

Original languageEnglish (US)
Pages (from-to)380-388
Number of pages9
JournalJournal of Surgical Research
Issue number4
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Surgery

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