Structural analysis of non-native states of proteins by NMR methods

Research output: Contribution to journalArticlepeer-review


Established NMR methods are increasingly being applied to the non-native states of proteins. For small denatured proteins, full assignment of proton, 15N and 13C resonances is often straightforward. Sensitive methods exist for detecting fractionally populated α helices and β strands, but defining transient interactions among side chains is proving more problematic. The non-native states of several small proteins are being intensively investigated to address a number of questions about protein folding.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalCurrent Opinion in Structural Biology
Issue number1
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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