Strong inhibition of xenografted tumor growth by low-level doses of [32P]ATP

Yulan Cheng, Jian Yang, Rachana Agarwal, Gilbert M. Green, Ron C. Mease, Martin G. Pomper, Stephen J. Meltzer, John M. Abraham

Research output: Contribution to journalArticle

Abstract

The ability of a potential human anti-cancer therapeutic agent to inhibit the growth of xenografted tumors in nude mice has been an established and accepted testing method for several decades. The current report shows that a single, low-level intravenous dose of [32P]ATP significantly inhibits the growth of established xenografted tumors in nude mice. This inhibitory effect becomes appreciable very rapidly, within only five days post-injection and the low dose demonstrates little or no toxicity in the mice. Surprisingly, a narrow dose window of optimum effectiveness is seen, whereby either decreasing or increasing the [32P]ATP dose results in far less growth inhibition. Thus, the intravenous systemic injection of [32P]ATP may represent a simple, potent method to target and inhibit primary human tumors and malignant lesions.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalOncotarget
Volume2
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Inhibition
  • Nude mice
  • Xenografts

ASJC Scopus subject areas

  • Oncology

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