Strong inhibition of xenografted tumor growth by low-level doses of [ 32P]ATP

Yulan Cheng, Jian Yang, Rachana Agarwal, Gilbert M. Green, Ronnie Mease, Martin Gilbert Pomper, Stephen Meltzer, John M. Abraham

Research output: Contribution to journalArticle

Abstract

The ability of a potential human anti-cancer therapeutic agent to inhibit the growth of xenografted tumors in nude mice has been an established and accepted testing method for several decades. The current report shows that a single, low-level intravenous dose of [ 32P]ATP significantly inhibits the growth of established xenografted tumors in nude mice. This inhibitory effect becomes appreciable very rapidly, within only five days post-injection and the low dose demonstrates little or no toxicity in the mice. Surprisingly, a narrow dose window of optimum effectiveness is seen, whereby either decreasing or increasing the [ 32P]ATP dose results in far less growth inhibition. Thus, the intravenous systemic injection of [ 32P]ATP may represent a simple, potent method to target and inhibit primary human tumors and malignant lesions.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalOncotarget
Volume2
Issue number6
StatePublished - Jun 2011

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Adenosine Triphosphate
Growth
Nude Mice
Neoplasms
Intravenous Injections
Injections
Therapeutics

Keywords

  • Inhibition
  • Nude mice
  • Xenografts

ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

Cite this

Cheng, Y., Yang, J., Agarwal, R., Green, G. M., Mease, R., Pomper, M. G., ... Abraham, J. M. (2011). Strong inhibition of xenografted tumor growth by low-level doses of [ 32P]ATP. Oncotarget, 2(6), 461-466.

Strong inhibition of xenografted tumor growth by low-level doses of [ 32P]ATP. / Cheng, Yulan; Yang, Jian; Agarwal, Rachana; Green, Gilbert M.; Mease, Ronnie; Pomper, Martin Gilbert; Meltzer, Stephen; Abraham, John M.

In: Oncotarget, Vol. 2, No. 6, 06.2011, p. 461-466.

Research output: Contribution to journalArticle

Cheng, Y, Yang, J, Agarwal, R, Green, GM, Mease, R, Pomper, MG, Meltzer, S & Abraham, JM 2011, 'Strong inhibition of xenografted tumor growth by low-level doses of [ 32P]ATP', Oncotarget, vol. 2, no. 6, pp. 461-466.
Cheng, Yulan ; Yang, Jian ; Agarwal, Rachana ; Green, Gilbert M. ; Mease, Ronnie ; Pomper, Martin Gilbert ; Meltzer, Stephen ; Abraham, John M. / Strong inhibition of xenografted tumor growth by low-level doses of [ 32P]ATP. In: Oncotarget. 2011 ; Vol. 2, No. 6. pp. 461-466.
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