Strong association between failure of T cell homeostasis and the syncytium-inducing phenotype among HIV-1-infected men in the Amsterdam Cohort Study

Jaap J.J. Maas, Stephen J. Gange, Hanneke Schuitemaker, Roel A. Coutinho, Remko Van Leeuwen, Joseph B. Margolick

Research output: Contribution to journalArticle

Abstract

Objective: To assess the association between T cell homeostasis and its failure and 1.) the occurence of AIDS and 2.) the switch from the non-syncytium-inducing (NSI) to the syncytium-inducing (SI) HIV virus phenotype. Methods: For each of 325 homosexual men in the Amsterdam Cohort Study, the slope of the CD3 T cell count versus time was determined. The timing (T cell inflection point (IP)) and magnitude of the change in slope were correlated with the time of the NSI/SI switch. Results: Median T cell slopes before the IP (pre-IP) were nearly zero regardless of whether AIDS occurred; the slopes after the IP (post-IP) were associated with clinical outcomes, with a median annual decline of 17.6% among those who developed AIDS and increase of 4.6% in those remaining AIDS free. Among subjects considered to have a true IP (decline > 8.2%/year post-IP), the times of the SI switch and the IP slope were highly correlated (r = 0.65); among those with AIDS, the SI switch preceded the IP by a median of 0.63 years. Conclusion: These results support the concept of blind T cell homeostasis and also suggest that HIV-1 SI variants play an important role in the failure of T cell homeostasis. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)1155-1161
Number of pages7
JournalAIDS
Volume14
Issue number9
DOIs
StatePublished - Jul 12 2000

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Keywords

  • AIDS
  • Blind T cell homeostasis
  • CD4 cell count
  • HIV
  • Progression
  • SI virus phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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