Stroke patients' evolving symptoms assessed by tractography

Kei Yamada, Hirotoshi Ito, Hisao Nakamura, Osamu Kizu, Wataru Akada, Takao Kubota, Mariko Goto, Jyunya Konishi, Kenji Yoshikawa, Kensuke Shiga, Masanori Nakagawa, Susumu Mori, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

Purpose: To test the hypothesis that an interval evolution in the location of the depicted sensorimotor tract relative to the infarct (the "tract-infarct relationship") may be related to stroke victims' symptom progression. Materials and Methods: Patients (N = 7) who underwent multiple diffusion-tensor imaging (DTI) studies during symptomatic progression were included in this study. DTI was performed using a single-shot echo-planar imaging (EPI) technique with a motion-probing gradient in six orientations, a b-value of 800 seconds/mm2, and six image averages. The total scan time was four minutes and 24 seconds. Fiber-tracking of the sensorimotor pathways was performed, and the locations of these tracts were retrospectively assessed in relation to the evolution of the symptoms. Results: Five of the seven patients showed an interval enlargement of the infarct on diffusion-weighted (DW) images. In two of these cases the lesion enlarged to involve the sensorimotor tracts, while in three cases the lesion enlarged only so far to come into close proximity to the sensorimotor tract. In the remaining two cases there was no interval enlargement of the infarct, and therefore the tract-infarct relationship could not account for the evolution of the symptoms in these cases. Conclusion: A tract-infarct relationship can be observed with the use of a fiber-tracking technique, and the results may improve our understanding of the symptom progression seen in stroke victims.

Original languageEnglish (US)
Pages (from-to)923-929
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume20
Issue number6
DOIs
StatePublished - Dec 1 2004

Keywords

  • Diffusion-tensor imaging
  • Diffusion-weighted image
  • Infarction
  • MRI
  • Stroke-in-evolution

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Yamada, K., Ito, H., Nakamura, H., Kizu, O., Akada, W., Kubota, T., Goto, M., Konishi, J., Yoshikawa, K., Shiga, K., Nakagawa, M., Mori, S., & Nishimura, T. (2004). Stroke patients' evolving symptoms assessed by tractography. Journal of Magnetic Resonance Imaging, 20(6), 923-929. https://doi.org/10.1002/jmri.20215