Striking the target in Wnt-y conditions: Intervening in Wnt signaling during cancer progression

Tura C. Camilli, Ashani T. Weeraratna

Research output: Contribution to journalReview articlepeer-review

Abstract

Wnt signaling can be divided into three pathways, namely the canonical Wnt/β-catenin pathway, and the non-canonical (or heretical) Wnt/Ca2+ and planar cell polarity (PCP) pathways. Although the canonical Wnt/β-catenin pathway is the best described in cancer, increasing data points to the importance of the heretical Wnt pathways in several aspects of tumor progression. The recent advances in understanding the players and mechanisms by which these Wnt pathways contribute to cancer progression have led to the identification of numerous molecules that are already, or could be considered, targets for cancer therapy.

Original languageEnglish (US)
Pages (from-to)702-711
Number of pages10
JournalBiochemical Pharmacology
Volume80
Issue number5
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Calcium
  • Cancer
  • PCP
  • Wnt
  • Wnt5A
  • β-Catenin

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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