Striatum specific protein, Rhes regulates AKT pathway

Sookhee Bang, Catherine Steenstra, Sangwon F. Kim

Research output: Contribution to journalArticlepeer-review

Abstract

The Rhes/RASD2 GTPase complex is involved in dopamine D1/D2 receptor-mediated signaling and behavior. This GTP binding protein belongs to the RAS superfamily, along with Dexras1/RASD1, and is primarily expressed in the striatum. RASDs differ from typical small GTPases as they have an extended C-terminal tail of roughly 7. kDa. Previously, it has been shown that dopamine depletion reduces Rhes mRNA expression in the brain. Here we show that Rhes interacts with p85, the regulatory subunit of PI3K. Specifically, the C-terminal unique tail region of Rhes is responsible for this interaction. The interaction between p85 and the C-terminal region of Rhes is enhanced upon growth factor treatment in vitro, while AKT translocation to the membrane is facilitated in the presence of Rhes or the Rhes-p85 complex. These findings suggest that Rhes is a novel striatal regulator of the AKT-mediated pathway in the striatum.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalNeuroscience Letters
Volume521
Issue number2
DOIs
StatePublished - Jul 19 2012
Externally publishedYes

Keywords

  • AKT signal transduction
  • Protein-protein interaction
  • Rhes/RASD2

ASJC Scopus subject areas

  • Neuroscience(all)

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