Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents

Sarah M. Helfinstein, Brenda Benson, Koraly Perez-Edgar, Yair Bar-Haim, Allison Detloff, Daniel S. Pine, Nathan A. Fox, Monique Ernst

Research output: Contribution to journalArticle

Abstract

The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.

Original languageEnglish (US)
Pages (from-to)479-485
Number of pages7
JournalNeuropsychologia
Volume49
Issue number3
DOIs
StatePublished - Feb 2011
Externally publishedYes

Fingerprint

Corpus Striatum
Reward
Aptitude
Prefrontal Cortex
Cues
Oxygen

Keywords

  • FMRI
  • Motivation
  • Reward
  • Striatum
  • Temperament
  • VmPFC

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Helfinstein, S. M., Benson, B., Perez-Edgar, K., Bar-Haim, Y., Detloff, A., Pine, D. S., ... Ernst, M. (2011). Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents. Neuropsychologia, 49(3), 479-485. https://doi.org/10.1016/j.neuropsychologia.2010.12.015

Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents. / Helfinstein, Sarah M.; Benson, Brenda; Perez-Edgar, Koraly; Bar-Haim, Yair; Detloff, Allison; Pine, Daniel S.; Fox, Nathan A.; Ernst, Monique.

In: Neuropsychologia, Vol. 49, No. 3, 02.2011, p. 479-485.

Research output: Contribution to journalArticle

Helfinstein, SM, Benson, B, Perez-Edgar, K, Bar-Haim, Y, Detloff, A, Pine, DS, Fox, NA & Ernst, M 2011, 'Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents', Neuropsychologia, vol. 49, no. 3, pp. 479-485. https://doi.org/10.1016/j.neuropsychologia.2010.12.015
Helfinstein, Sarah M. ; Benson, Brenda ; Perez-Edgar, Koraly ; Bar-Haim, Yair ; Detloff, Allison ; Pine, Daniel S. ; Fox, Nathan A. ; Ernst, Monique. / Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents. In: Neuropsychologia. 2011 ; Vol. 49, No. 3. pp. 479-485.
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