Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents

Sarah M. Helfinstein; Brenda Benson; Koraly Perez-Edgar; Yair Bar-Haim; Allison Detloff; Daniel S. Pine; Nathan A. Fox; Monique Ernst

doi:10.1016/j.neuropsychologia.2010.12.015

Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents

Sarah M. Helfinstein, Brenda Benson, Koraly Perez-Edgar, Yair Bar-Haim, Allison Detloff, Daniel S. Pine, Nathan A. Fox, Monique Ernst

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.

Original language	English (US)
Pages (from-to)	479-485
Number of pages	7
Journal	Neuropsychologia
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/j.neuropsychologia.2010.12.015
State	Published - Feb 2011
Externally published	Yes

Keywords

FMRI
Motivation
Reward
Striatum
Temperament
VmPFC

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.neuropsychologia.2010.12.015

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title = "Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents",

abstract = "The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.",

keywords = "FMRI, Motivation, Reward, Striatum, Temperament, VmPFC",

author = "Helfinstein, {Sarah M.} and Brenda Benson and Koraly Perez-Edgar and Yair Bar-Haim and Allison Detloff and Pine, {Daniel S.} and Fox, {Nathan A.} and Monique Ernst",

note = "Funding Information: This work was supported in part by the National Institute of Mental Health Grant R01 MH 074454 (N.A.F.), the National Institute of Child Health and Development Grant 5R37 HD 017899-20 (N.A.F.), the Intramural Research Program of the National Institutes of Health—National Institute of Mental Health, and by a National Science Foundation Graduate Research Fellowship (S.M.H.).",

year = "2011",

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doi = "10.1016/j.neuropsychologia.2010.12.015",

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AU - Benson, Brenda

AU - Perez-Edgar, Koraly

AU - Bar-Haim, Yair

AU - Detloff, Allison

AU - Pine, Daniel S.

AU - Fox, Nathan A.

AU - Ernst, Monique

N1 - Funding Information: This work was supported in part by the National Institute of Mental Health Grant R01 MH 074454 (N.A.F.), the National Institute of Child Health and Development Grant 5R37 HD 017899-20 (N.A.F.), the Intramural Research Program of the National Institutes of Health—National Institute of Mental Health, and by a National Science Foundation Graduate Research Fellowship (S.M.H.).

PY - 2011/2

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N2 - The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.

AB - The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.

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KW - Reward

KW - Striatum

KW - Temperament

KW - VmPFC

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Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents

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Keywords

ASJC Scopus subject areas

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