Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage

Andreas Heinz, Richard C. Saunders, Bhaskar S. Kolachana, Douglas W. Jones, Julia G. Gorey, Jocelyne Bachevalier, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

Developmental cortical damage has been implicated in the basic neurobiology of schizophrenia. Adult rhesus monkeys with neonatal temporal limbic damage show a stimulus-dependent disinhibition of subcortical dopamine (DA) release. We measured dopamine D2 receptors and transporters in vivo in rhesus monkeys with neonatal and adult mesial temporal limbic lesions and control monkeys to explore further the effects of this developmental lesion on striatal DA function. All monkeys were studied with [I-123]IBZM SPECT to assess the availability of striatal dopamine D2 receptors and with [I- 123]β-CIT SPECT to measure the availability of dopamine transporters in the striatum. IBZM binding was significantly reduced in monkeys with neonatal limbic lesions. No group difference in β-CIT binding was found. The reduction in IBZM binding was significantly correlated with subcortical dopamine release after monoaminergic prefrontal stimulation as determinated with in vivo microdialysis. Our findings imply specific interactions between age at lesion and the availability of DA transporter and receptors in non- human primates, and suggest that stimulus-dependent DA activity affects the expression of DA receptors.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalSynapse
Volume32
Issue number2
DOIs
StatePublished - Apr 15 1999
Externally publishedYes

Fingerprint

Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Dopamine Receptors
Haplorhini
Dopamine
Dopamine D2 Receptors
Single-Photon Emission-Computed Tomography
Macaca mulatta
Neurobiology
Microdialysis
Primates
Schizophrenia
3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide

Keywords

  • β-CIT SPECT
  • IBZM SPECT
  • Neurodevelopmental hypothesis
  • Phasic dopamine release
  • Prefrontal regulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pharmacology

Cite this

Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage. / Heinz, Andreas; Saunders, Richard C.; Kolachana, Bhaskar S.; Jones, Douglas W.; Gorey, Julia G.; Bachevalier, Jocelyne; Weinberger, Daniel.

In: Synapse, Vol. 32, No. 2, 15.04.1999, p. 71-79.

Research output: Contribution to journalArticle

Heinz, Andreas ; Saunders, Richard C. ; Kolachana, Bhaskar S. ; Jones, Douglas W. ; Gorey, Julia G. ; Bachevalier, Jocelyne ; Weinberger, Daniel. / Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage. In: Synapse. 1999 ; Vol. 32, No. 2. pp. 71-79.
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