TY - JOUR
T1 - Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage
AU - Heinz, Andreas
AU - Saunders, Richard C.
AU - Kolachana, Bhaskar S.
AU - Jones, Douglas W.
AU - Gorey, Julia G.
AU - Bachevalier, Jocelyne
AU - Weinberger, Daniel R.
PY - 1999/4/15
Y1 - 1999/4/15
N2 - Developmental cortical damage has been implicated in the basic neurobiology of schizophrenia. Adult rhesus monkeys with neonatal temporal limbic damage show a stimulus-dependent disinhibition of subcortical dopamine (DA) release. We measured dopamine D2 receptors and transporters in vivo in rhesus monkeys with neonatal and adult mesial temporal limbic lesions and control monkeys to explore further the effects of this developmental lesion on striatal DA function. All monkeys were studied with [I-123]IBZM SPECT to assess the availability of striatal dopamine D2 receptors and with [I- 123]β-CIT SPECT to measure the availability of dopamine transporters in the striatum. IBZM binding was significantly reduced in monkeys with neonatal limbic lesions. No group difference in β-CIT binding was found. The reduction in IBZM binding was significantly correlated with subcortical dopamine release after monoaminergic prefrontal stimulation as determinated with in vivo microdialysis. Our findings imply specific interactions between age at lesion and the availability of DA transporter and receptors in non- human primates, and suggest that stimulus-dependent DA activity affects the expression of DA receptors.
AB - Developmental cortical damage has been implicated in the basic neurobiology of schizophrenia. Adult rhesus monkeys with neonatal temporal limbic damage show a stimulus-dependent disinhibition of subcortical dopamine (DA) release. We measured dopamine D2 receptors and transporters in vivo in rhesus monkeys with neonatal and adult mesial temporal limbic lesions and control monkeys to explore further the effects of this developmental lesion on striatal DA function. All monkeys were studied with [I-123]IBZM SPECT to assess the availability of striatal dopamine D2 receptors and with [I- 123]β-CIT SPECT to measure the availability of dopamine transporters in the striatum. IBZM binding was significantly reduced in monkeys with neonatal limbic lesions. No group difference in β-CIT binding was found. The reduction in IBZM binding was significantly correlated with subcortical dopamine release after monoaminergic prefrontal stimulation as determinated with in vivo microdialysis. Our findings imply specific interactions between age at lesion and the availability of DA transporter and receptors in non- human primates, and suggest that stimulus-dependent DA activity affects the expression of DA receptors.
KW - IBZM SPECT
KW - Neurodevelopmental hypothesis
KW - Phasic dopamine release
KW - Prefrontal regulation
KW - β-CIT SPECT
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U2 - 10.1002/(SICI)1098-2396(199905)32:2<71::AID-SYN1>3.0.CO;2-Q
DO - 10.1002/(SICI)1098-2396(199905)32:2<71::AID-SYN1>3.0.CO;2-Q
M3 - Article
C2 - 10231127
AN - SCOPUS:0033561362
SN - 0887-4476
VL - 32
SP - 71
EP - 79
JO - Synapse
JF - Synapse
IS - 2
ER -