Striatal binding of the PET ligand 11C‐raclopride is altered by drugs that modify synaptic dopamine levels

Stephen L. Dewey, Gwenn S. Smith, Jean Logan, Jonathan D. Brodie, Joanna S. Fowler, Alfred P. Wolf

Research output: Contribution to journalArticlepeer-review

Abstract

Bilatera decreases in striatal 11C‐raclopride binding were observed in adult female baboons with high resolution PET following administration of drugs that act centrally on dopaminergic neurons. At baseline and following administration of d‐amphetamine (a dopamine‐releasing drug), GBR‐12909 (a potent dopamine reuptake inhibitor), or tetrabenazine (a biogenic amine depleting drug) PET scans of 11C‐raclopride binding were obtained in a CTI 931 positron tomograph. In all studies, the ratio of the distribution volumes for the striatum to the cerebellum for 11C‐raclopride binding decreased significantly by an average of 16.2% for d‐amphetamine, 22.1% for GBR‐12909, and 28.3% for tetrabenazine while there were no significant changes observed in the cerebellum or in the rate of systemic metabolism of the radiotracer. These decreases exceed the test/retest variability of striatal 11C‐raclopride binding measured in the same animals under identical experimental conditions (Dewey et al., 1992b). Together these studies demonstrate that PET measurements of striatal 11C‐raclopride binding can be used to indirectly and non‐invasively monitor changes in synaptic dopamine concentrations that result from a variety of neurophysiologic mechanisms. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalSynapse
Volume13
Issue number4
DOIs
StatePublished - Apr 1993
Externally publishedYes

Keywords

  • Amphetamine
  • Baboon
  • Dopamine
  • GBR‐12909
  • Positron emission tomography
  • Striatum
  • Tetrabenazine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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