Striatal antibodies in children with Tourette's syndrome: Multivariate discriminant analysis of IgG repertoires

John T. Wendlandt, Franz H. Grus, Bendt H. Hansen, Harvey S. Singer

Research output: Contribution to journalArticle

Abstract

Antineuronal antibodies have been postulated to be the underlying pathophysiology in TS and other neuropsychiatric disorders. Serum antibodies from 20 children with TS, and 21 control subjects against human striatum, globus pallidus, muscle, and HTB-10 cells were assayed by Western blot techniques. A MANOVA differentiated between TS and control blots, and a discriminant analysis demonstrated which variables contributed most to differences between groups. Prominent differences between TS and control blots were identified using striatal epitopes in contrast to similar patterns shown between groups for globus pallidus, muscle and HTB-10 tissue, supporting striatal autoimmune involvement in TS pathophysiology.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalJournal of Neuroimmunology
Volume119
Issue number1
DOIs
StatePublished - Sep 3 2001

Keywords

  • Antineuronal antibodies
  • Discriminant analysis
  • IgG repertoire
  • Tourette's syndrome
  • Western blot

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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