Stressing the role of O-GlcNAc: Linking cell survival to keratin modification

Jeremy D. Rotty, Gerald Warren Hart, Pierre A. Coulombe

Research output: Contribution to journalArticle

Abstract

Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

Original languageEnglish (US)
Pages (from-to)847-849
Number of pages3
JournalNature Cell Biology
Volume12
Issue number9
DOIs
StatePublished - 2010

Fingerprint

Keratins
Cell Survival
Keratin-18
Acetylglucosamine
Post Translational Protein Processing
Glycosylation

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Stressing the role of O-GlcNAc : Linking cell survival to keratin modification. / Rotty, Jeremy D.; Hart, Gerald Warren; Coulombe, Pierre A.

In: Nature Cell Biology, Vol. 12, No. 9, 2010, p. 847-849.

Research output: Contribution to journalArticle

Rotty, Jeremy D. ; Hart, Gerald Warren ; Coulombe, Pierre A. / Stressing the role of O-GlcNAc : Linking cell survival to keratin modification. In: Nature Cell Biology. 2010 ; Vol. 12, No. 9. pp. 847-849.
@article{b2a3633515fc43c79ad5aee7d7e3f1f3,
title = "Stressing the role of O-GlcNAc: Linking cell survival to keratin modification",
abstract = "Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.",
author = "Rotty, {Jeremy D.} and Hart, {Gerald Warren} and Coulombe, {Pierre A.}",
year = "2010",
doi = "10.1038/ncb0910-847",
language = "English (US)",
volume = "12",
pages = "847--849",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Stressing the role of O-GlcNAc

T2 - Linking cell survival to keratin modification

AU - Rotty, Jeremy D.

AU - Hart, Gerald Warren

AU - Coulombe, Pierre A.

PY - 2010

Y1 - 2010

N2 - Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

AB - Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

UR - http://www.scopus.com/inward/record.url?scp=77956401599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956401599&partnerID=8YFLogxK

U2 - 10.1038/ncb0910-847

DO - 10.1038/ncb0910-847

M3 - Article

C2 - 20811358

AN - SCOPUS:77956401599

VL - 12

SP - 847

EP - 849

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 9

ER -