Stressing the role of O-GlcNAc: Linking cell survival to keratin modification

Jeremy D. Rotty, Gerald W. Hart, Pierre A. Coulombe

Research output: Contribution to journalReview articlepeer-review

Abstract

Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

Original languageEnglish (US)
Pages (from-to)847-849
Number of pages3
JournalNature cell biology
Volume12
Issue number9
DOIs
StatePublished - Sep 2010

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Stressing the role of O-GlcNAc: Linking cell survival to keratin modification'. Together they form a unique fingerprint.

Cite this