Stress response factors drive regrowth of quiescent cells

Zheng Kuang, Hong Kai Ji, Jef D. Boeke

Research output: Contribution to journalArticle

Abstract

Quiescent cells exploit an array of transcription factors to activate stress response machinery and maintain survival under nutrient-limited conditions. Our recent findings reveal that these transcription factors also play an important role in the exit of quiescence and regrowth. By studying Saccharomyces cerevisiae under a continuous, nutrient-limited condition, we found that Msn2 and Msn4 function as master regulators of glycolytic genes in the quiescent-like phase. They control the timing of transition from quiescence to growth by regulating the accumulation rate of acetyl-CoA, a key metabolite that is downstream of glycolysis and drives growth. These findings suggest a model that Msn2/4 not only protect the cells from starvation but also facilitate their regrowth from quiescence. Thus, understanding the functions of stress response transcription factors in metabolic regulation will provide deeper insight into how quiescent cells manage the capacity of regrowth.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalCurrent Genetics
DOIs
StateAccepted/In press - Feb 17 2018

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Transcription Factors
Food
Acetyl Coenzyme A
Glycolysis
Regulator Genes
Growth
Starvation
Saccharomyces cerevisiae

Keywords

  • Acetyl-CoA
  • Glycolysis
  • Msn2
  • Msn4
  • Quiescence exit
  • Regrowth

ASJC Scopus subject areas

  • Genetics

Cite this

Stress response factors drive regrowth of quiescent cells. / Kuang, Zheng; Ji, Hong Kai; Boeke, Jef D.

In: Current Genetics, 17.02.2018, p. 1-4.

Research output: Contribution to journalArticle

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