Stress oxidative: Nephrolithiasis and chronic kidney diseases

S. R. Khan

Research output: Contribution to journalArticle

Abstract

The association between nephrolithiasis and many chronic kidney diseases suggests a common causative link. There are indications that stone formation can lead to hypertension, diabetes, chronic disease and myocardial infarct. The reverse also appears to be true in that diabetes and hypertension can lead to stone formation. The production of reactive oxygen species (ROS) and the development of oxidative stress (OS) are common features of many renal and cardiovascular diseases including, hypertension, diabetes, metabolic syndrome and nephrolithiasis. It is my hypothesis that oxidative stress produced by one disease may lead to another under suitable conditions. For example mild hypercalciuria, hyperoxaluria, hypocitraturia which under normal conditions may just be a curiosity or nuisance can promote crystallization when cells are injured by ROS produced by the co-morbid condition. On the other hand OS produced during or as a result of nephrolithiasis may promote hypertension or diabetic nephropathy.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalMinerva Medica
Volume104
Issue number1
Publication statusPublished - Feb 2013
Externally publishedYes

    Fingerprint

Keywords

  • Atherosclerosis
  • Diabetes
  • Hypertension
  • Kidney failure, chronic
  • Metabolic syndrome
  • Nephrolithiasis
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this