TY - JOUR
T1 - Stress, mindfulness, and systemic lupus erythematosus
T2 - An overview and directions for future research
AU - Molina, Emily
AU - Gould, Neda
AU - Lee, Kristen
AU - Krimins, Rebecca
AU - Hardenbergh, Dylan
AU - Timlin, Homa
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/11
Y1 - 2022/11
N2 - Although the pathogenesis of autoimmunity is not fully understood, it is thought to involve genetic, hormonal, immunologic, and environmental factors. Stress has been evaluated as a potential trigger for autoimmunity and disease flares in patients with systemic lupus erythematosus (SLE). The physiologic changes that occur with stress involve numerous catecholamines, hormones, and cytokines that communicate intricately with the immune system. There is some evidence that these systems may be dysregulated in patients with autoimmune disease. Mindfulness-based techniques are practices aimed at mitigating stress response and have been shown to improve quality of life in general population. This review will discuss pathophysiology of chronic stress as it relates to SLE, evidence behind mindfulness-based practices in these patients, and directions for future research.
AB - Although the pathogenesis of autoimmunity is not fully understood, it is thought to involve genetic, hormonal, immunologic, and environmental factors. Stress has been evaluated as a potential trigger for autoimmunity and disease flares in patients with systemic lupus erythematosus (SLE). The physiologic changes that occur with stress involve numerous catecholamines, hormones, and cytokines that communicate intricately with the immune system. There is some evidence that these systems may be dysregulated in patients with autoimmune disease. Mindfulness-based techniques are practices aimed at mitigating stress response and have been shown to improve quality of life in general population. This review will discuss pathophysiology of chronic stress as it relates to SLE, evidence behind mindfulness-based practices in these patients, and directions for future research.
KW - mindfulness
KW - stress
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85136683014&partnerID=8YFLogxK
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U2 - 10.1177/09612033221122980
DO - 10.1177/09612033221122980
M3 - Review article
C2 - 35998903
AN - SCOPUS:85136683014
SN - 0961-2033
VL - 31
SP - 1549
EP - 1562
JO - Lupus
JF - Lupus
IS - 13
ER -