Abstract
Central serotonergic (5-HT) and noradrenergic (NA) neurons, which innervate the same regions of the brain, are known to play a crucial role in emotion and mood. These monoamine neurons have a great capacity to alter axonal morphology in response to repeated stress. The morphological responses of 5-HT and NA axons to repeated stress are different, and they sometimes even demonstrate opposite responses (namely, either sprouting or degeneration). Moreover, a morphological interaction also occurs between 5-HT and NA axons during axonal regeneration. This review describes the differential features of axonal plasticity of 5-HT and NA neurons in relation to stress, and discusses the possible roles that the morphological plasticity of 5-HT and NA axons may play in the pathophysiology of depression.
Original language | English (US) |
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Pages (from-to) | 1794-1801 |
Number of pages | 8 |
Journal | Frontiers in Bioscience |
Volume | 11 |
Issue number | 2 P.1591-2006 |
DOIs | |
State | Published - 2006 |
Keywords
- Depression
- Neuroplasticity
- Noradrenaline
- Serotonin
- Stress
- Yamaguchi 755-8505
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology